Electrochemical behaviour and determination of acrivastine in pharmaceuticals and human urine

The differential pulse polarography, DC-tast polarography and cyclic voltarnmetry behaviour of acrivastine was studied in Britton-Robinson buffer solutions (pH 2-11.7). In acidic media, a non-reversible diffusion controlled reduction process involving four electrons takes place. Two reduction waves appear at a E-1/2 = -0.6 and 0.99 V. The reduction mechanism is discussed. The linear relationship between peak current height and acrivastine concentration allowed the differential pulse polarographic determination of acrivastine over a wide concentration range, from 0.35 to 26.1 mg 1(-1) at pH 2.5. The procedure was applied to determination of the drug in pharmaceutical formulations and human urine samples. (C) 2002 Elsevier Science B.V. All rights reserved.