Lamins: Building blocks or regulators of gene expression?

被引：237
作者：
Hutchison, CJ [1 ]
机构：
[1] Univ Durham, Dept Biol & Biomed Sci, Durham DH1 3LE, England
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2002年 / 3卷 / 11期
基金：
英国惠康基金;
关键词：
D O I：
10.1038/nrm950
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Intermediate filament (IF) proteins are the building blocks of cytoskeletal filaments, the main function of which is to maintain cell shape and integrity. The lamins are thought to be the evolutionary progenitors of IF proteins and they have profound influences on both nuclear structure and function. These influences require the lamins to have dynamic properties and dual identities - as building blocks and transcriptional regulators. Which one of these identities underlies a myriad of genetic diseases is a topic of intense debate.
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收藏
页码：848 / 858
页数：11
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