Fabrication and properties of CaSiO3/Sr3(PO4)2 composite scaffold based on extrusion deposition

In recent years, 3D printing technology has been increasingly used to fabricate porous bone scaffolds for treating bone tissue defects. Calcium silicate (CS) is a bioceramic material with broad application prospects, but the characteristics of poor sintering performance and fast degradation have limited its further application. In this paper, porous CS scaffolds with different proportions of strontium phosphate (Sr-3(PO4)(2)) were formed by pneumatic extrusion deposition. Experiments showed that the Sr element replaced the Ca element in CaSiO3, which altered the crystal structure of CaSiO3, changed its physical and chemical properties, and improved the sintering property of CS ceramics. At the same time, the substituted Ca element formed Ca-3(PO4)(2). After mixing Ca-3(PO4)(2) and CaSiO3, the grain of CaSiO3 was refined and the sintering property was improved. Because of this dual role, the Sr element improved the sintering property of CaSiO3 ceramics and delayed the degradation of CS ceramics. Moreover, cell experiments showed that the addition of the Sr element had a positive effect on cell proliferation and differentiation.