The Association Between Age at Initiation of Alcohol Consumption and Type 2 Diabetes Mellitus: A Cohort Study of 0.5 Million Persons in China

被引：8
作者：
Li, Haoxin [1 ,2 ]
Lv, Jun [1 ,2 ,10 ,11 ]
Yu, Canqing [1 ,2 ]
Guo, Yu [3 ]
Bian, Zheng [3 ]
Fan, Junning [1 ,2 ]
Yang, Ling [4 ,5 ,6 ]
Chen, Yiping [4 ,5 ,6 ]
Du, Huaidong [4 ,5 ,6 ]
Long, Huajun [8 ]
Zhang, Zengzhi [9 ]
Chen, Junshi [7 ]
Chen, Zhengming [5 ,6 ]
Huang, Tao [1 ,2 ]
Li, Liming [1 ,2 ]
机构：
[1] Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing, Peoples R China
[2] Peking Univ, Hlth Sci Ctr, Beijing, Peoples R China
[3] Chinese Acad Med Sci, Beijing, Peoples R China
[4] Univ Oxford, Populat Hlth Res Unit, MRC, Oxford, England
[5] Univ Oxford, Clin Trial Serv Unit, Nuffield Dept Populat Hlth, Med Sci Div, Oxford, England
[6] Univ Oxford, Epidemiol Studies Unit, Nuffield Dept Populat Hlth, Med Sci Div, Oxford, England
[7] China Natl Ctr Food Safety Risk Assessment, Beijing, Peoples R China
[8] Liuyang Ctr Dis Control, NCDs Prevent & Control Dept, Liuyang, Peoples R China
[9] Shinan Ctr Dis Control, Prevent & Control Dept, Shinan, Peoples R China
[10] Peking Univ, Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
[11] Peking Univ, Inst Environm Med, Beijing, Peoples R China
来源：
AMERICAN JOURNAL OF EPIDEMIOLOGY | 2020年 / 189卷 / 12期
基金：
中国国家自然科学基金; 英国惠康基金; 英国医学研究理事会;
关键词：
alcohol; alcohol consumption; Chinese; cohort studies; drinking duration; type; 2; diabetes; 1ST DRINK; ADULT ALCOHOL; ONSET; DEPENDENCE; METAANALYSIS; PANCREAS; DAMAGE; ABUSE; RISK;
D O I：
10.1093/aje/kwaa119
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
It is well known that alcohol consumption is associated with type 2 diabetes mellitus. However, the association of age at initiation of alcohol consumption and duration of alcohol drinking with type 2 diabetes mellitus among Chinese adults is not fully understood. This study was based on data from the China Kadoorie Biobank, which included 512,712 participants aged 30-79 years who were living in China in 2004-2008. A Cox proportional hazards model was used to estimate the association of AAI and drinking duration with type 2 diabetes. After adjustment for potential covariates, ages at alcohol initiation (AAIs) of 18.1-29.0 years, 29.1-39.0 years, and >39.0 years were associated with 22% (95% confidence interval (CI): 14, 30), 25% (95% CI: 17, 33), and 32% (95% CI: 24, 39) lower hazards of type 2 diabetes compared with abstaining, respectively. Drinking durations of <10.1 years, 10.1-20.0 years, and 20.1-30.0 years were associated with a lower risk of type 2 diabetes, compared with abstaining. Among current (weekly) drinkers, AAI <18.1 years and drinking duration >30.0 years were associated with 18% (95% CI: 4, 33) and 20% (95% CI: 3, 40) higher hazards of type 2 diabetes, compared with AAI 18.1-29.0 years and drinking duration <10.1 years, respectively. In conclusion, late AAI and a short drinking duration were associated with a lower risk of type 2 diabetes in this large prospective cohort study of Chinese adults, but early AAI and long drinking duration were not.
引用
收藏
页码：1478 / 1491
页数：14
相关论文
共 32 条
[1]   Evidence for an Interaction Between Age at First Drink and Genetic Influences on DSM-IV Alcohol Dependence Symptoms [J].
Agrawal, Arpana ;
Sartor, Carolyn E. ;
Lynskey, Michael T. ;
Grant, Julia D. ;
Pergadia, Michele L. ;
Grucza, Richard ;
Bucholz, Kathleen K. ;
Nelson, Elliot C. ;
Madden, Pamela A. F. ;
Martin, Nicholas G. ;
Heath, Andrew C. .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2009, 33 (12) :2047-2056
[2]  
[Anonymous], 2014, GLOB STAT REP VIOL
[3]  
[Anonymous], 2017, 69 NONC DIS PROGR MO
[4]   Alcohol consumption and risk of type 2 diabetes in European men and women: influence of beverage type and body size The EPIC-InterAct study [J].
Beulens, J. W. J. ;
van der Schouw, Y. T. ;
Bergmann, M. M. ;
Rohrmann, S. ;
Schulze, M. B. ;
Buijsse, B. ;
Grobbee, D. E. ;
Arriola, L. ;
Cauchi, S. ;
Tormo, M-J ;
Allen, N. E. ;
van der A, D. L. ;
Balkau, B. ;
Boeing, H. ;
Clavel-Chapelon, F. ;
de Lauzon-Guillan, B. ;
Franks, P. ;
Froguel, P. ;
Gonzales, C. ;
Halkjaer, J. ;
Huerta, J. M. ;
Kaaks, R. ;
Key, T. J. ;
Khaw, K. T. ;
Krogh, V. ;
Molina-Montes, E. ;
Nilsson, P. ;
Overvad, K. ;
Palli, D. ;
Panico, S. ;
Ramon Quiros, J. ;
Ronaldsson, O. ;
Romieu, I. ;
Romaguera, D. ;
Sacerdote, C. ;
Sanchez, M-J ;
Spijkerman, A. M. W. ;
Teucher, B. ;
Tjonneland, A. ;
Tumino, R. ;
Sharp, S. ;
Forouhi, N. G. ;
Langenberg, C. ;
Feskens, E. J. M. ;
Riboli, E. ;
Wareham, N. J. .
JOURNAL OF INTERNAL MEDICINE, 2012, 272 (04) :358-370
[5]   China Kadoorie Biobank of 0.5 million people: survey methods, baseline characteristics and long-term follow-up [J].
Chen, Zhengming ;
Chen, Junshi ;
Collins, Rory ;
Guo, Yu ;
Peto, Richard ;
Wu, Fan ;
Li, Liming .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2011, 40 (06) :1652-1666
[6]   Chronic saponin treatment attenuates damage to the pancreas in chronic alcohol-treated diabetic rats [J].
Choi, Mi Ran ;
Kwak, Su Min ;
Bang, Sol Hee ;
Jeong, Jo-Eun ;
Kim, Dai-Jin .
JOURNAL OF GINSENG RESEARCH, 2017, 41 (04) :503-512
[7]   Age at First Drink and the First Incidence of Adult-Onset DSM-IV Alcohol Use Disorders [J].
Dawson, Deborah A. ;
Goldstein, Rise B. ;
Chou, S. Patricia ;
Ruan, W. June ;
Grant, Bridget F. .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2008, 32 (12) :2149-2160
[8]   Age of onset of drug use and its association with DSM-IV drug abuse and dependence: Results from the National Longitudinal Alcohol Epidemiologic Survey [J].
Grant, BF ;
Dawson, DA .
JOURNAL OF SUBSTANCE ABUSE, 1998, 10 (02) :163-173
[9]   Age at onset of alcohol use and DSM-IV alcohol abuse and dependence: A 12-year follow-up [J].
Grant, BF ;
Stinson, FS ;
Harford, TC .
JOURNAL OF SUBSTANCE ABUSE, 2001, 13 (04) :493-504
[10]   Adolescent alcohol use is a risk factor for adult alcohol and drug dependence: evidence from a twin design [J].
Grant, JD ;
Scherrer, JF ;
Lynskey, MT ;
Lyons, MJ ;
Eisen, SA ;
Tsuang, MT ;
True, WR ;
Bucholz, KK .
PSYCHOLOGICAL MEDICINE, 2006, 36 (01) :109-118
1234