Access to the Pyrroloindoline Core via [3+2] Annulation as well as the Application in the Synthetic Approach to (±)-Minfiensine

被引：95

作者：

Ji, Wenzhi ^{[1
]}

Yao, Licheng ^{[1
]}

Liao, Xuebin ^{[1
]}

机构：

[1] Tsinghua Univ, Dept Pharmacol & Pharmaceut Sci, Sch Med, Collaborat Innovat Ctr Diag & Treatment Infect Di, Beijing 100084, Peoples R China

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 03期

关键词：

ENANTIOSELECTIVE TOTAL-SYNTHESIS; IMINIUM ION CYCLIZATION; CONCISE TOTAL-SYNTHESIS; CYCLOADDITION REACTIONS; CONSTRUCTION; INDOLES; CASCADE; CYCLOPENTANNULATION; TRYPTAMINES; MINFIENSINE;

D O I：

10.1021/acs.orglett.5b03421

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A [3 + 2] formal cycloaddition reaction using aza-oxyallyl cation as a synthetic synthon was developed to construct the pyrroloindololine core. With this novel method, a variety of C3-substituted indoles were readily converted into the corresponding pyrroloindoline analogues at room temperature in the mixed solvents. To further demonstrate the utility of this method, a synthetic approach to the total synthesis of (+/-)-minfiensine was developed in quite concise fashion.

引用

收藏

页码：628 / 630

页数：3

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