A Case Report of Pregnancy During Use of Targeted Therapeutics for Cystic Fibrosis

被引：24

作者：

Ladores, Sigrid ^{[1
]}

Kazmerski, Traci M. ^{[2
]}

Rowe, Steven M. ^{[3
,4
,5
]}

机构：

[1] Univ Alabama Birmingham, Sch Nursing, 1720 2nd Ave South,NB 304, Birmingham, AL 35294 USA

[2] Boston Childrens Hosp, Div Resp Dis, Boston, MA USA

[3] Univ Alabama Birmingham, Cyst Fibrosis Res Ctr, Birmingham, AL USA

[4] Vertex Pharmaceut, Boston, MA USA

[5] Univ Alabama Birmingham, Birmingham, AL USA

来源：

JOGNN-JOURNAL OF OBSTETRIC GYNECOLOGIC AND NEONATAL NURSING | 2017年 / 46卷 / 01期

关键词：

cystic fibrosis; fertility; ivacaftor; lumacaftor/ivacaftor; sexual and reproductive health; TRANSMEMBRANE CONDUCTANCE REGULATOR; BICARBONATE SECRETION; WOMEN; CFTR; POTENTIATOR; IVACAFTOR; AIRWAY; IMPACT;

D O I：

10.1016/j.jogn.2016.08.011

中图分类号：

R47 [护理学];

学科分类号：

1011 ;

摘要：

New therapeutics, such as ivacaftor, and the combination drug lumacaftor/ ivacaftor that target the underlying genetic cause of cystic fibrosis are being hailed as game-changers in this era of personalized medicine. Although these drugs improve lung function, their effects on female fertility have not been studied. In this case report we describe one woman's experience with ivacaftor and her unanticipated pregnancy. Implications related to comprehensive sexual and reproductive health care for women with cystic fibrosis are presented.

引用

页码：72 / 77

页数：6

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