Body composition changes in diabetes and aging

被引：117
作者：
Al-Sofiani, Mohammed E. [1 ,2 ]
Ganji, Suneeta S. [1 ]
Kalyani, Rita R. [1 ]
机构：
[1] Johns Hopkins Univ, Div Endocrinol Diabet & Metab, Baltimore, MD USA
[2] King Saud Univ, Coll Med, Div Endocrinol, Riyadh, Saudi Arabia
来源：
JOURNAL OF DIABETES AND ITS COMPLICATIONS | 2019年 / 33卷 / 06期
基金：
美国国家卫生研究院;
关键词：
Diabetes; Body composition; Lean mass; Fat mass; Aging; Muscle mass; ADIPOSE-TISSUE DISTRIBUTION; LIVER FAT-CONTENT; MUSCLE STRENGTH; GLYCEMIC CONTROL; OLDER-ADULTS; RESISTANCE EXERCISE; INSULIN SENSITIVITY; VISCERAL ADIPOSITY; ENERGY-EXPENDITURE; GLUCOSE-TOLERANCE;
D O I：
10.1016/j.jdiacomp.2019.03.007
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Aging is associated with changes in body composition, including both fat gain and muscle loss beginning in middle age, and is associated with increased risk of type 2 diabetes. Moreover, changes in fat distribution take place in adults as they age and may contribute to the increased risk of type 2 diabetes. Recent literature has shown differences in the age-related changes in body composition by diabetes status suggesting that some of these changes might not only be a risk factor of the development of diabetes but could also be a consequence of the disease. In this article, we review the current evidence on body composition changes that take place in adults after the diagnosis of type 2 diabetes and compare them to those observed in adults without diabetes as they age. We also review the effect of various lifestyle, pharmacological, and surgical treatments that lower blood glucose on body composition in adults with type 2 diabetes. (C) 2019 Elsevier Inc. All rights reserved.
引用
收藏
页码：451 / 459
页数：9
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