A G4•K+ Hydrogel Stabilized by an Anion

被引：174

作者：

Peters, Gretchen Marie ^{[1
]}

Skala, Luke P. ^{[1
]}

Plank, Taylor N. ^{[1
]}

Hyman, Brooke J. ^{[1
]}

Reddy, G. N. Manjunatha ^{[2
]}

Marsh, Andrew ^{[3
]}

Brown, Steven P. ^{[2
]}

Davis, Jeffery T. ^{[1
]}

机构：

[1] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA

[2] Univ Warwick, Dept Phys, Coventry CV4 7AL, W Midlands, England

[3] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 36期

基金：

英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

G-QUADRUPLEXES; BORATE; NMR; ESTERS; LONG; DYES;

D O I：

10.1021/ja507506c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Supramolecular hydrogels derived from natural products have promising applications in diagnostics, drug delivery, and tissue engineering. We studied the formation of a long-lived hydrogel made by mixing guanosine (G, 1) with 0.5 equiv of KB(OH)(4). This ratio of borate anion to ligand is crucial for gelation as it links two molecules of 1, which facilitates cation-templated assembly of G4 center dot K+ quartets. The guanosineborate (GB) hydrogel, which was characterized by cryogenic transmission electron microscopy and circular dichroism and 11B magic-angle-spinning NMR spectroscopy, is stable in water that contains physiologically relevant concentrations of K+. Furthermore, non-covalent interactions, such as electrostatics, ?-stacking, and hydrogen bonding, enable the incorporation of a cationic dye and nucleosides into the GB hydrogel.

引用

页码：12596 / 12599

页数：4

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