Intercellular Communication by Extracellular Vesicles and Their MicroRNAs in Asthma

被引：78

作者：

Fujita, Yu ^{[1
,2
]}

Yoshioka, Yusuke ^{[1
]}

Ito, Saburo ^{[2
]}

Araya, Jun ^{[2
]}

Kuwano, Kazuyoshi ^{[2
]}

Ochiya, Takahiro ^{[1
]}

机构：

[1] Natl Canc Ctr, Res Inst, Div Mol & Cellular Med, Tokyo 1040045, Japan

[2] Jikei Univ, Sch Med, Dept Internal Med, Div Resp Dis, Tokyo, Japan

来源：

CLINICAL THERAPEUTICS | 2014年 / 36卷 / 06期

基金：

日本学术振兴会;

关键词：

allergy; asthma; cell-to-cell communication; exosome; extracellular vesicles; microRNA; BRONCHOALVEOLAR LAVAGE FLUID; CIRCULATING MICRORNAS; EXOSOMES; CELLS; MICROVESICLES; MECHANISM; DISCOVERY; BIOMARKER; DISEASE; IMPACT;

D O I：

10.1016/j.clinthera.2014.05.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Purpose: Extracellular vesicles (EVs) such as exosomes and microvesicles are phospholipid bilayer enclosed vesicles that are recognized as novel tools for intercellular communications and as biomarkers for several diseases. They contain various DNAs, proteins, mRNAs, and microRNAs (miRNAs) that have potential diagnostic and therapeutic purposes. Their biological roles have attracted significant interest in the pulmonary field because their vesicle composition and miRNA content have the ability to transfer biological information to recipient cells and play an important role in pulmonary inflammatory and allergic diseases. Asthma is a chronic inflammatory disease of the airways, and it is characterized by variable and recurring symptoms and reversible airflow obstruction. The purpose of this review was to discuss the function of EVs and their miRNAs in asthma, with a focus on the biological properties and biogenesis of EVs, their pathophysiologic roles, and their potential use as biomarkers and therapies for asthma. Methods: We review the findings from several articles on EVs and their miRNAs in asthma and provide illustrative references. Findings: A few studies have reported on the biological function of bronchoalveolar lavage fluid derived EVs in asthmatic progression. In the lungs, EVs might regulate airway inflammation and allergic reactions through their paracrine effects. Furthermore, circulating miRNAs have been found to be associated with EVs. Implication: EV-mediated miRNAs can be used as biomarkers in asthma. (C) 2014 Elsevier HS Journals, Inc. All rights reserved.

引用

页码：873 / 881

页数：9

共 57 条

[1] Exosomes -: nanovesicles with possible roles in allergic inflammation [J].

Admyre, C. ;

Telemo, E. ;

Almqvist, N. ;

Lotvall, J. ;

Lahesmaa, R. ;

Scheynius, A. ;

Gabrielsson, S. .

ALLERGY, 2008, 63 (04) :404-408

[2] Exosomes with major histocompatibility complex class II and co-stimulatory molecules are present in human BAL fluid [J].

Admyre, C ;

Grunewald, J ;

Thyberg, J ;

Gripenbäck, S ;

Tornling, G ;

Eklund, A ;

Scheynius, A ;

Gabrielsson, S .

EUROPEAN RESPIRATORY JOURNAL, 2003, 22 (04) :578-583

[3] Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma [J].

Arroyo, Jason D. ;

Chevillet, John R. ;

Kroh, Evan M. ;

Ruf, Ingrid K. ;

Pritchard, Colin C. ;

Gibson, Donald F. ;

Mitchell, Patrick S. ;

Bennett, Christopher F. ;

Pogosova-Agadjanyan, Era L. ;

Stirewalt, Derek L. ;

Tait, Jonathan F. ;

Tewari, Muneesh .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (12) :5003-5008

[4] The impact of microRNAs on protein output [J].

Baek, Daehyun ;

Villen, Judit ;

Shin, Chanseok ;

Camargo, Fernando D. ;

Gygi, Steven P. ;

Bartel, David P. .

NATURE, 2008, 455 (7209) :64-U38

[5] Immune response modifiers in the treatment of asthma: A PRACTALL document of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology [J].

Ballow, Mark ;

Akdis, Cezmi A. ;

Casale, Thomas B. ;

Wardlaw, Andrew J. ;

Wenzel, Sally E. ;

Ballas, Zuhair ;

Lotvall, Jan .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2012, 130 (02) :311-324

[6] Exosomes: New players in cell-cell communication [J].

Bang, Claudia ;

Thum, Thomas .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2012, 44 (11) :2060-2064

[7] Exosomal-like vesicles are present in human blood plasma [J].

Caby, MP ;

Lankar, D ;

Vincendeau-Scherrer, C ;

Raposo, G ;

Bonnerot, C .

INTERNATIONAL IMMUNOLOGY, 2005, 17 (07) :879-887

[8] Exosomes: immune properties and potential clinical implementations [J].

Chaput, Nathalie ;

Thery, Clotilde .

SEMINARS IN IMMUNOPATHOLOGY, 2011, 33 (05) :419-440

[9] MicroRNAs and Their Therapeutic Potential for Human Diseases: MiR-133a and Bronchial Smooth Muscle Hyperresponsiveness in Asthma [J].

Chiba, Yoshihiko ;

Misawa, Miwa .

JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010, 114 (03) :264-268

[10] MicroRNAs in body fluids-the mix of hormones and biomarkers [J].

Cortez, Maria Angelica ;

Bueso-Ramos, Carlos ;

Ferdin, Jana ;

Lopez-Berestein, Gabriel ;

Sood, Anil K. ;

Calin, George A. .

NATURE REVIEWS CLINICAL ONCOLOGY, 2011, 8 (08) :467-477

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