Mixed steroidal tetraoxanes induce apoptotic cell death in tumor cells

被引：26

作者：

Zizak, Zeljko ^{[1
]}

Juranic, Zorica ^{[1
]}

Opsenica, Dejan ^{[2
]}

Solaja, Bogdan A. ^{[3
]}

机构：

[1] Inst Oncol & Radiol Serbia, Belgrade 11000, Serbia

[2] Inst Chem Technol & Met, Belgrade 11000, Serbia

[3] Univ Belgrade, Fac Chem, Belgrade, Serbia

来源：

INVESTIGATIONAL NEW DRUGS | 2009年 / 27卷 / 05期

关键词：

Tetraoxanes; Apoptosis; Cytotoxicity; Anticancer agents; RAPID COLORIMETRIC ASSAY; ANTIMALARIAL ACTIVITY; ARTEMISININ; 1,2,4,5-TETRAOXANES; DISPIRO-1,2,4,5-TETRAOXANES; ENDOPEROXIDES; DNA;

D O I：

10.1007/s10637-008-9197-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this study we investigated the antiproliferative activity of six mixed steroidal tetraoxanes against various tumor cell lines, the toxicity against normal peripheral blood mononuclear cells (PBMC), and the mode of HeLa cell death induced by these compounds. Investigated tetraoxanes exerted a dose dependent antiproliferative action at micromolar concentrations toward target tumor cell lines. Treatment of HeLa cells for 24 h with all tetraoxanes induced apoptosis, as confirmed by morphological analysis and by the appearance of a typical ladder pattern in the DNA fragmentation assay.

引用

页码：432 / 439

页数：8

共 27 条

[1] Design and synthesis of orally active dispiro 1,2,4,5-tetraoxanes; synthetic antimalarials with superior activity to artemisinin [J].