Research in high flow therapy: Mechanisms of action

被引：532

作者：

Dysart, Kevin ^{[1
,2
,3
]}

Miller, Thomas L. ^{[1
,4
]}

Wolfson, Maria R. ^{[5
,6
]}

Shaffer, Thomas H. ^{[1
,2
,3
,5
,6
]}

机构：

[1] Thomas Jefferson Univ, Jefferson Med Coll, Dept Pediat, Philadelphia, PA 19107 USA

[2] Nemours, Dept Pediat, Wilmington, DE USA

[3] Nemours, Dept Biomed Res, Wilmington, DE USA

[4] Vapotherm Inc, Stevensville, MD USA

[5] Temple Univ, Sch Med, Dept Physiol, Philadelphia, PA 19122 USA

[6] Temple Univ, Sch Med, Dept Pediat, Philadelphia, PA 19122 USA

来源：

RESPIRATORY MEDICINE | 2009年 / 103卷 / 10期

关键词：

High flow nasal canula; Oxygen therapy; Humidification device; Nasal canula; POSITIVE AIRWAY PRESSURE; TRACHEAL GAS INSUFFLATION; RESPIRATORY-DISTRESS SYNDROME; HYALINE-MEMBRANE DISEASE; NASAL CANNULA; PRETERM INFANTS; INHALATION; RESISTANCE; DEVICE; VENTILATION;

D O I：

10.1016/j.rmed.2009.04.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recently, heater/humidifier devices that use novel methods to condition breathing gases from an external source have been introduced. The addition of sufficient warmth and high levels of humidification to breathing gas has allowed for higher flow rates from nasal cannula devices to be applied to patients (i.e., high flow therapy). This article provides a review of the proposed mechanisms behind the efficacy of high flow therapy via nasal cannula, which include washout of nasopharyngeal. dead space, attenuation of the inspiratory resistance associated with the nasopharynx, improvement in conductance and pulmonary compliance, mild distending pressure and reduction in energy expenditure for gas conditioning. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1400 / 1405

页数：6

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