Urinary apolipoprotein M as a biomarker of acute kidney injury in children undergoing heart surgery

被引：11

作者：

Svarrer, Eva Martha Madsen ^{[1
]}

Andersen, Henrik Orbaek ^{[2
]}

Helvind, Morten ^{[2
]}

Slagman, Maartje C. J. ^{[3
]}

Navis, Gerjan ^{[3
]}

Dullaart, Robin P. F. ^{[4
]}

Dahlback, Bjoern ^{[5
]}

Nielsen, Lars Bo ^{[1
,6
,7
]}

机构：

[1] Univ Copenhagen, Rigshosp, Dept Clin Biochem, DK-1168 Copenhagen, Denmark

[2] Univ Copenhagen, Rigshosp, Dept Cardiothorac Surg, DK-1168 Copenhagen, Denmark

[3] Univ Groningen, Univ Med Ctr Groningen, Dept Nephrol, NL-9713 GZ Groningen, Netherlands

[4] Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, NL-9713 GZ Groningen, Netherlands

[5] Lund Univ, Univ Hosp, Div Clin Chem, Dept Lab Med, Malmo, Sweden

[6] Univ Copenhagen, Dept Biomed Sci, DK-1168 Copenhagen, Denmark

[7] Univ Copenhagen, Dept Clin Med, DK-1168 Copenhagen, Denmark

来源：

BIOMARKERS IN MEDICINE | 2016年 / 10卷 / 01期

关键词：

acute kidney injury; AKI; apoM; Apolipoprotein M; biomarker; cardiac surgery; urine; GELATINASE-ASSOCIATED LIPOCALIN; HIGH-DENSITY-LIPOPROTEIN; ACUTE RENAL INJURY; TISSUE EXPRESSION; RISK; NGAL; INFLAMMATION; CHOLESTEROL; RECEPTOR; OUTCOMES;

D O I：

10.2217/bmm.15.105

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: To investigate whether apoM is excreted in urine of children undergoing heart surgery and the potential of apoM as early biomarker of acute kidney injury (AKI). Materials & methods: Urine was collected in children undergoing heart surgery. ApoM was measured with ELISA. U-apoM was characterized by gel filtration chromatography and western blotting. Results: ApoM was excreted into the urine 0-4 h postoperatively as the full-length apoM in particles smaller than plasma HDL. At 0 h, U-apoM predicted AKI with an area under the receiver-operating characteristics curve of 0.70 (p < 0.018). Sensitivity was 0.71 and specificity was 0.68 at a cutoff level at 1.45 nmol/l. Conclusion: ApoM is excreted in the urine of children after cardiac surgery. Its potential as biomarker of AKI deserves exploration.

引用

页码：81 / 93

页数：13

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