Targeting NF-κB Signaling in Multiple Myeloma

被引:0
作者
Bergsagel, P. Leif [1 ]
Keats, J. Jonathan [1 ]
Chesi, Marta [1 ]
Kuehl, W. Michael [2 ]
机构
[1] Mayo Clin, Scottsdale, AZ USA
[2] NCI, Bethesda, MD 20892 USA
关键词
CELL-GROWTH; INHIBITOR; PATHWAY;
D O I
10.1016/S1557-9190(11)70807-1
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:S14 / S16
页数:3
相关论文
共 10 条
[1]   Frequent engagement of the classical and alternative NF-κB pathways by diverse genetic abnormalities in multiple myeloma [J].
Annunziata, Christina M. ;
Davis, R. Eric ;
Demchenko, Yulia ;
Bellamy, William ;
Gabrea, Ana ;
Zhan, Fenghuang ;
Lenz, Georg ;
Hanamura, Ichiro ;
Wright, George ;
Xiao, Wenming ;
Dave, Sandeep ;
Hurt, Elaine M. ;
Tan, Bruce ;
Zhao, Hong ;
Stephens, Owen ;
Santra, Madhumita ;
Williams, David R. ;
Dang, Lenny ;
Barlogie, Bart ;
Shaughnessy, John D., Jr. ;
Kuehl, W. Michael ;
Staudt, Louis M. .
CANCER CELL, 2007, 12 (02) :115-130
[2]   Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma [J].
Bergsagel, PL ;
Kuehl, WM ;
Zhan, FH ;
Sawyer, J ;
Barlogie, B ;
Shaughnessy, J .
BLOOD, 2005, 106 (01) :296-303
[3]   Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B [J].
Chauhan, D ;
Uchiyama, H ;
Akbarali, Y ;
Urashima, M ;
Yamamoto, K ;
Libermann, TA ;
Anderson, KC .
BLOOD, 1996, 87 (03) :1104-1112
[4]   NF-κB as a therapeutic target in multiple myeloma [J].
Hideshima, T ;
Chauhan, D ;
Richardson, P ;
Mitsiades, C ;
Mitsiades, N ;
Hayashi, T ;
Munshi, N ;
Dang, L ;
Castro, A ;
Palombella, V ;
Adams, J ;
Anderson, KC .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (19) :16639-16647
[5]   MLN120B, a novel IκB kinase β inhibitor, blocks multiple myeloma cell growth in vitro and in vivo [J].
Hideshima, Teru ;
Neri, Paola ;
Tassone, Pierfranchesco ;
Yasui, Hiroshi ;
Ishitsuka, Kenji ;
Raje, Noopur ;
Chauhan, Dharminder ;
Podarl, Klaus ;
Mitsiades, Constantine ;
Dang, Lenny ;
Munshi, Nikhil ;
Richardson, Paul ;
Schenkein, David ;
Anderson, Kenneth C. .
CLINICAL CANCER RESEARCH, 2006, 12 (19) :5887-5894
[6]   Targeting NF-κB pathway with an IKK2 inhibitor induces inhibition of multiple myeloma cell growth [J].
Jourdan, Michel ;
Moreaux, Jerome ;
De Vos, John ;
Hose, Dirk ;
Mahtouk, Karene ;
Abouladze, Matthieu ;
Robert, Nicolas ;
Baudard, Marion ;
Reme, Thierry ;
Romanelli, Angela ;
Goldschmidt, Hartmut ;
Rossi, Jean-Francois ;
Dreano, Michel ;
Klein, Bernard .
BRITISH JOURNAL OF HAEMATOLOGY, 2007, 138 (02) :160-168
[7]   Promiscuous mutations activate the noncanonical NF-κB pathway in multiple myeloma [J].
Keats, Jonathan J. ;
Fonseca, Rafael ;
Chesi, Marta ;
Schop, Roelandt ;
Baker, Angela ;
Ching, Wee-Joo ;
Van Wier, Scott ;
Tiedemann, Rodger ;
Shi, Chang-Xin ;
Sebag, Michael ;
Braggio, Esteban ;
Henry, Travis ;
Zhu, Yuan-Xiao ;
Fogle, Homer ;
Price-Troska, Tammy ;
Ahmann, Gregory ;
Mancini, Catherine ;
Brents, Leslie A. ;
Kumar, Shaji ;
Greipp, Philip ;
Dispenzieri, Angela ;
Bryant, Barb ;
Mulligan, George ;
Bruhn, Laurakay ;
Barrett, Michael ;
Valdez, Riccardo ;
Trent, Jeff ;
Stewart, A. Keith ;
Carpten, John ;
Bergsagel, P. Leif .
CANCER CELL, 2007, 12 (02) :131-144
[8]   Multiple myeloma: Evolving genetic events and host interactions [J].
Kuehl, WM ;
Bergsagel, PL .
NATURE REVIEWS CANCER, 2002, 2 (03) :175-187
[9]   BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone [J].
Moreaux, J ;
Legouffe, E ;
Jourdan, E ;
Quittet, P ;
Rème, T ;
Lugagne, C ;
Moine, P ;
Rossi, JF ;
Klein, B ;
Tarte, K .
BLOOD, 2004, 103 (08) :3148-3157
[10]   Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling [J].
Vallabhapurapu, Sivakumar ;
Matsuzawa, Atsushi ;
Zhang, WeiZhou ;
Tseng, Ping-Hui ;
Keats, Jonathan J. ;
Wang, Haopeng ;
Vignali, Dario A. A. ;
Bergsagel, P. Leif ;
Karin, Michael .
NATURE IMMUNOLOGY, 2008, 9 (12) :1364-1370