Antimicrobial activity of some N-alkyl substituted of (E)-4-azachalconium and (E)-3′-hydroxy-4-azachalconium bromides

Twelve new N-substituted (E)-azachalconium bromides were synthesized and tested for antimicrobial and antifungal activities. Compounds 5c, 5d and 5h-5I showed very good antimicrobial activity against Staphylococcus aureus, Enterococcus faecalis as well as Bacillus subtilis and 5h-5j showed moderate activity against Escherichia coli. In particular, (E)-N-dodecyl-4-azachalconium bromide (5i) and (E)-N-tetradecyl-4-azachalconium bromide (5j) showed the most intensive activity against all tested microorganisms. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.