Transposable elements in brain health and disease

被引：25

作者：

Ahmadi, Amirhossein ^{[1
]}

De Toma, Ilario ^{[2
]}

Vilor-Tejedor, Natalia ^{[3
,4
,5
]}

Ghamsari, Mohammad Reza Eftekhariyan ^{[6
]}

Sadeghi, Iman ^{[7
,8
]}

机构：

[1] Persian Gulf Univ, Dept Biol, Fac Sci, Bushehr 75169, Iran

[2] Ctr Genom Regulat CRG, Syst Biol Program, Cellular & Syst Neurobiol, Barcelona, Spain

[3] Barcelona Inst Sci & Technol, Ctr Genom Regulat CRG, Dr Aiguader 88, Barcelona 08003, Spain

[4] Pasqual Maragall Fdn, BarcelonaBeta Brain Res Ctr BBRC, Barcelona, Spain

[5] Erasmus MC, Dept Clin Genet, Rotterdam, Netherlands

[6] Olivia Newton John Canc Res Inst, Melbourne, Vic, Australia

[7] CEINGE Biotecnol Avanzate, Naples, Italy

[8] Barcelona Inst Sci & Technol, CRG, Dr Aiguader 88, E-08003 Barcelona, Spain

来源：

AGEING RESEARCH REVIEWS | 2020年 / 64卷

关键词：

Transposable elements; Brain development; Brain disorders; Retrotransposon; Neuroplasticity; HUMAN ENDOGENOUS RETROVIRUS; NON-LTR RETROTRANSPOSONS; MULTIPLE-SCLEROSIS; L1; RETROTRANSPOSITION; SOMATIC RETROTRANSPOSITION; DNA METHYLATION; LINE-1; ELEMENTS; TRANSCRIPTIONAL ACTIVITY; SVA RETROTRANSPOSONS; STRUCTURAL VARIATION;

D O I：

10.1016/j.arr.2020.101153

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Transposable elements (TEs) occupy a large fraction of the human genome but only a small proportion of these elements are still active today. Recent works have suggested that TEs are expressed and active in the brain, challenging the dogma that neuronal genomes are static and revealing that they are susceptible to somatic genomic alterations. These new findings have major implications for understanding the neuroplasticity of the brain, which could hypothetically have a role in behavior and cognition, and contribute to vulnerability to disease. As active TEs could induce genetic diversity and mutagenesis, their influences on human brain development and diseases are of great interest. In this review, we will focus on the active TEs in the human genome and discuss in detail their impacts on human brain development. Furthermore, the association between TEs and brain-related diseases is discussed.

引用

页数：16

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