The moisture sorption isotherms of cefotaxime sodium salt

被引：5

作者：

Acosta, J ^{[1
]}

Nuevas, L ^{[1
]}

Rodríguez, I ^{[1
]}

Pardillo, E ^{[1
]}

Ramos, A ^{[1
]}

机构：

[1] Ctr Quim Farmaceut, Havana 11600, Cuba

来源：

DRYING TECHNOLOGY | 2000年 / 18卷 / 1-2期

关键词：

cefotaxime; isosteric heat; moisture adsorption isotherms;

D O I：

10.1080/07373930008917717

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

The water sorption isotherms of the cefotaxime sodium salt were determined at 30 and 40 degrees C. Cefotaxime sodium salt was maintained at equilibrium relative humidities ranging from 40 to 80%. Equilibrium moisture content was determined by the Karl Fischer method. The moisture sorption isotherms showed that the equilibrium moisture decrease while the temperature increase. The experimental curves of equilibrium humidity were fitted by different models (Bradley, Halsey, Henderson, Kuhn, Smith and Iglesias and Chirife and GAB). Parameters of each equations were determined by non-linear regression analysis. The best fit was obtained by Iglesias and Chirife model. The isosteric heat of moisture sorption calculated by Claussius Clapeyron equation varied from 64.45 to 48.03 kJ/mol when moisture content changed from 7 to 9.5%.

引用

页码：469 / 477

页数：9

共 14 条

[1]

AGUERRE RJ, 1989, LEBENSM WISS TECHNOL, V22, P19

[2] MOISTURE SORPTION ISOTHERMS OF DRIED APRICOT, FIG AND RAISIN AT 20-DEGREE-C AND 36-DEGREE-C [J].