A Facile Synthesis of 3-(Arylthio)imidazo[1,2-a]pyridin-2(3H)-ones from 2-Aminopyridinium Bromides and Sodium Arenesulfinates

被引：3

作者：

Saroj ^{[1
]}

Rangan, Krishnan ^{[2
]}

Kumar, Anil ^{[1
]}

机构：

[1] Birla Inst Technol & Sci Pilani, Dept Chem, Pilani Campus, Pilani 333031, Rajasthan, India

[2] Birla Inst Technol & Sci Pilani, Dept Chem, Hyderabad Campus, Hyderabad 500078, Telangana, India

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 2020卷 / 45期

关键词：

2-Aminopyridinium salt; Amidation; Cyclization; Imidazo[1,2-a]pyridine-2(3H)one; Sulfenylation; C-H FUNCTIONALIZATION; REGIOSELECTIVE SULFENYLATION; PYRIDINE-DERIVATIVES; SULFUR POWDER; IMIDAZOHETEROCYCLES; IMIDAZOPYRIDINES; THIOLATION; THIOETHERS; ARYLSULFENYLATION; CHALCOGENATION;

D O I：

10.1002/ejoc.202000996

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and convenient method has been developed for the synthesis of 3-(arylthio)imidazo[1,2-a]pyridin-2(3H)-ones through a catalyst-free reaction of 2-aminopyridinium bromides with sodium arenesulfinates. A variety of 3-(arylthio)imidazo[1,2-a]pyridin-2(3H)-ones were obtained in moderate to excellent (33-85 %) yields. The developed protocol is operationally simple, exhibits a broad substrate scope with a wide range of functional groups, and is amenable for gram-scale synthesis.

引用

页码：7015 / 7022

页数：8

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