Application of CRISPR-mediated genome engineering in cancer research

被引：14

作者：

Sayin, Volkan I. ^{[1
]}

Papagiannakopoulos, Thales ^{[1
]}

机构：

[1] NYU, Sch Med, Dept Pathol, 550 First Ave, New York, NY 10016 USA

来源：

CANCER LETTERS | 2017年 / 387卷

关键词：

CRISPR; Cas9; Genome engineering; Cancer; Mouse models; ONE-STEP GENERATION; LONG NONCODING RNAS; GENE-EXPRESSION; HUMAN-CELLS; CHROMOSOMAL REARRANGEMENTS; WIDE ASSOCIATION; MOUSE MODELS; DNA-CLEAVAGE; ACTIVATION; MUTATIONS;

D O I：

10.1016/j.canlet.2016.03.029

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer is a multistep process that arises from a series of genetic and epigenetic events. With recent technological advances there has been a burst in genome sequencing and epigenetic studies revealing a plethora of alterations that may contribute to cancer. However, the great challenge for the cancer research community is the systematic functional characterization of these genetic and epigenetic events to assess their role in cancer initiation and progression. Recent advances in genome engineering using CRISPR/Cas9, an ancient bacterial immune-like system, have revolutionized cancer genetics. Here we highlight the breakthroughs in the effective use of these novel genome-editing techniques, and we discuss the challenges and potential applications of these tools for cancer biology. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：10 / 17

页数：8

共 125 条

[1] Cloning-free CRISPR/Cas system facilitates functional cassette knock-in in mice [J].

Aida, Tomomi ;

Chiyo, Keiho ;

Usami, Takako ;

Ishikubo, Harumi ;

Imahashi, Risa ;

Wada, Yusaku ;

Tanaka, Kenji F. ;

Sakuma, Tetsushi ;

Yamamoto, Takashi ;

Tanaka, Kohichi .

GENOME BIOLOGY, 2015, 16

[2] Cancer-Associated Protein Kinase C Mutations Reveal Kinase's Role as Tumor Suppressor [J].

Antal, Corina E. ;

Hudson, Andrew M. ;

Kang, Emily ;

Zanca, Ciro ;

Wirth, Christopher ;

Stephenson, Natalie L. ;

Trotter, Eleanor W. ;

Gallegos, Lisa L. ;

Miller, Crispin J. ;

Fumari, Frank B. ;

Hunter, Tony ;

Brognard, John ;

Newton, Alexandra C. .

CELL, 2015, 160 (03) :489-502

[3] An Inducible Lentiviral Guide RNA Platform Enables the Identification of Tumor-Essential Genes and Tumor-Promoting Mutations In Vivo [J].

Aubrey, Brandon J. ;

Kelly, Gemma L. ;

Kueh, Andrew J. ;

Brennan, Margs S. ;

O'Connor, Liam ;

Milla, Liz ;

Wilcox, Stephen ;

Tai, Lin ;

Strasser, Andreas ;

Herold, Marco J. .

CELL REPORTS, 2015, 10 (08) :1422-1432

[4] Comprehensive molecular characterization of gastric adenocarcinoma [J].

Bass, Adam J. ;

Thorsson, Vesteinn ;

Shmulevich, Ilya ;

Reynolds, Sheila M. ;

Miller, Michael ;

Bernard, Brady ;

Hinoue, Toshinori ;

Laird, Peter W. ;

Curtis, Christina ;

Shen, Hui ;

Weisenberger, Daniel J. ;

Schultz, Nikolaus ;

Shen, Ronglai ;

Weinhold, Nils ;

Keiser, David P. ;

Bowlby, Reanne ;

Sipahimalani, Payal ;

Cherniack, Andrew D. ;

Getz, Gad ;

Liu, Yingchun ;

Noble, Michael S. ;

Pedamallu, Chandra ;

Sougnez, Carrie ;

Taylor-Weiner, Amaro ;

Akbani, Rehan ;

Lee, Ju-Seog ;

Liu, Wenbin ;

Mills, Gordon B. ;

Yang, Da ;

Zhang, Wei ;

Pantazi, Angeliki ;

Parfenov, Michael ;

Gulley, Margaret ;

Piazuelo, M. Blanca ;

Schneider, Barbara G. ;

Kim, Jihun ;

Boussioutas, Alex ;

Sheth, Margi ;

Demchok, John A. ;

Rabkin, Charles S. ;

Willis, Joseph E. ;

Ng, Sam ;

Garman, Katherine ;

Beer, David G. ;

Pennathur, Arjun ;

Raphael, Benjamin J. ;

Wu, Hsin-Ta ;

Odze, Robert ;

Kim, Hark K. ;

Bowen, Jay .

NATURE, 2014, 513 (7517) :202-209

[5] Cancer - Improved mouse models [J].

Berns, A .

NATURE, 2001, 410 (6832) :1043-1044

[6] Enhancing gene targeting with designed zinc finger nucleases [J].

Bibikova, M ;

Beumer, K ;

Trautman, JK ;

Carroll, D .

SCIENCE, 2003, 300 (5620) :764-764

[7] Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system [J].

Bikard, David ;

Jiang, Wenyan ;

Samai, Poulami ;

Hochschild, Ann ;

Zhang, Feng ;

Marraffini, Luciano A. .

NUCLEIC ACIDS RESEARCH, 2013, 41 (15) :7429-7437

[8] An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis [J].

Birsoy, Kivanc ;

Wang, Tim ;

Chen, Walter W. ;

Freinkman, Elizaveta ;

Abu-Remaileh, Monther ;

Sabatini, David M. .

CELL, 2015, 162 (03) :540-551

[9] Simple and Rapid In Vivo Generation of Chromosomal Rearrangements using CRISPR/Cas9 Technology [J].

Blasco, Rafael B. ;

Karaca, Elif ;

Ambrogio, Chiara ;

Cheong, Taek-Chin ;

Karayol, Emre ;

Minero, Valerio G. ;

Voena, Claudia ;

Chiarle, Roberto .

CELL REPORTS, 2014, 9 (04) :1219-1227

[10] Organoid Models of Human and Mouse Ductal Pancreatic Cancer [J].

Boj, Sylvia F. ;

Hwang, Chang-Il ;

Baker, Lindsey A. ;

Chio, Iok In Christine ;

Engle, Dannielle D. ;

Corbo, Vincenzo ;

Jager, Myrthe ;

Ponz-Sarvise, Mariano ;

Tiriac, Herve ;

Spector, Mona S. ;

Gracanin, Ana ;

Oni, Tobiloba ;

Yu, Kenneth H. ;

van Boxtel, Ruben ;

Huch, Meritxell ;

Rivera, Keith D. ;

Wilson, John P. ;

Feigin, Michael E. ;

Oehlund, Daniel ;

Handly-Santana, Abram ;

Ardito-Abraham, Christine M. ;

Ludwig, Michael ;

Elyada, Ela ;

Alagesan, Brinda ;

Biffi, Giulia ;

Yordanov, Georgi N. ;

Delcuze, Bethany ;

Creighton, Brianna ;

Wright, Kevin ;

Park, Youngkyu ;

Morsink, Folkert H. M. ;

Molenaar, I. Quintus ;

Rinkes, Inne H. Borel ;

Cuppen, Edwin ;

Hao, Yuan ;

Jin, Ying ;

Nijman, Isaac J. ;

Iacobuzio-Donahue, Christine ;

Leach, Steven D. ;

Pappin, Darryl J. ;

Hammell, Molly ;

Klimstra, David S. ;

Basturk, Olca ;

Hruban, Ralph H. ;

Offerhaus, George Johan ;

Vries, Robert G. J. ;

Clevers, Hans ;

Tuveson, David A. .

CELL, 2015, 160 (1-2) :324-338

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