Inflammation-induced cholestasis

被引：171

作者：

Trauner, M ^{[1
]}

Fickert, P ^{[1
]}

Stauber, RE ^{[1
]}

机构：

[1] Karl Franzens Univ Graz, Sch Med, Div Gastroenterol & Hepatol, Dept Internal Med, A-8036 Graz, Austria

来源：

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 1999年 / 14卷 / 10期

关键词：

cholestasis; cytokines; endotoxin; hepatocyte; inflammation; jaundice; transport;

D O I：

10.1046/j.1440-1746.1999.01982.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Inflammatory cytokines produced in response to various infectious and non-infectious stimuli are potent inducers of intrahepatic cholestasis (inflammation-induced cholestasis). The cholestatic effect of cytokines results mainly from inhibition of expression and function of hepatocellular transport systems which normally mediate hepatic uptake and biliary excretion of bile salts and various non-bile salt organic anions (e.g. bilirubin). These cytokine effects are reversible and bile secretory function is restored upon disappearance of the inflammatory injury. This review summarizes the clinical, pathophysiological and molecular aspects of inflammation-induced cholestasis. (C) 1999 Blackwell Science Asia Pry Ltd.

引用

页码：946 / 959

页数：14

共 142 条

[1]

Abrams G A, 1995, Gastroenterologist, V3, P220

[2]

ALBERTI A, 1999, OXFORD TXB CLIN HEPA, P903

[3] Regulation of cholangiocyte bile secretion [J].