CX3CR1-fractalkine expression regulates cellular mechanisms involved in adhesion, migration, and survival of human prostate cancer cells

被引：167
作者：
Shulby, SA
Dolloff, NG
Stearns, ME
Meucci, O
Fatatis, A
机构：
[1] Drexel Univ, Coll Med, Dept Pharmacol & Physiol, Philadelphia, PA 19102 USA
[2] Drexel Univ, Coll Med, Dept Pathol, Philadelphia, PA 19102 USA
来源：
CANCER RESEARCH | 2004年 / 64卷 / 14期
关键词：
D O I：
10.1158/0008-5472.CAN-03-3437
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Chemokines and their receptors might be involved in the selection of specific organs by metastatic cancer cells. For instance, the CXCR4-SDF-1alpha pair regulates adhesion and migration of breast as well as prostate cancer cells to metastatic sites. In this study, we present the first evidence for the expression of CX3CR1-the specific receptor for the chemokine fractalkine-by human prostate cancer cells, whereas human bone marrow endothelial cells and differentiated osteoblasts; express fractalkine. The adhesion of prostate cancer cells to human bone marrow endothelial cells in flow conditions is significantly reduced by a neutralizing antibody against fractalkine, and they migrate toward a medium conditioned by osteoblasts, which secrete the soluble form of the chemokine. Finally, fractalkine activates the PI3K/Akt survival pathway in human prostate cancer cells.
引用
收藏
页码：4693 / 4698
页数：6
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