Proactive strategy for long-term biological research aimed at low-dose radiation risk in Korea

被引:1
作者
Seong, Ki Moon [1 ]
Kwon, TaeWoo [1 ]
Park, Jina [1 ]
Youn, BuHyun [2 ]
Cha, Hyuk-Jin [3 ]
Kim, Yonghwan [4 ]
Moon, Changjong [5 ,6 ]
Lee, Seung-Sook [1 ,7 ]
Jin, Young Woo [1 ]
机构
[1] Korea Inst Radiol & Med Sci, Natl Radiat Emergency Med Ctr, Lab Low Dose Risk Assessment, Seoul 01812, South Korea
[2] Pusan Natl Univ, Dept Biol Sci, Busan, South Korea
[3] Seoul Natl Univ, Sch Pharm, Seoul, South Korea
[4] Sookmyung Womens Univ, Dept Biol Sci, Seoul, South Korea
[5] Chonnam Natl Univ, Dept Vet Anat, Coll Vet Med, Gwangju, South Korea
[6] Chonnam Natl Univ, PLUS Project Team BK21, Gwangju, South Korea
[7] Korea Inst Radiol & Med Sci, Dept Pathol, Korea Canc Ctr Hosp, Seoul, South Korea
关键词
Low-dose radiation; health risks; sustainable program; IONIZING-RADIATION; CANCER; MORTALITY; EXPOSURE; HEALTH; HORMESIS;
D O I
10.1080/09553002.2018.1478163
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Purpose: Since the 2011 Fukushima nuclear power plant accident, Korean radiation experts have agreed that reliable data on health risks of low-dose radiation (LDR) are needed to ease the anxiety of lay people. The intent of this study was to devise a sustainable biological program suited for the research environment in Korea and aimed at the health effects of radiation exposures <100 millisieverts (mSv). To address pressing public concerns over LDR risk, we investigated the current understanding of LDR effects by analyzing the previous reports of international authorities for radiation protection and research publications that appeared after the Chernobyl accident. A research program appropriate for societal and scientific inclinations of Korea was then devised based on input from Korean radiation scientists.Conclusions: After review by our advisory committee, program priorities were set, calling for an agenda that focused on dose-response relationships in carcinogenesis, health span responses to lifestyle variations, and systemic metabolic changes. Our long-term biological research program may contribute scientific evidence to reduce the uncertainties of LDR health risks and help stakeholders formulate policies for radiation protection.
引用
收藏
页码:685 / 693
页数:9
相关论文
共 42 条
  • [1] [Anonymous], 2012, BIOL MECH RAD ACT LO
  • [2] Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury
    Azzam, Edouard I.
    Jay-Gerin, Jean-Paul
    Pain, Debkumar
    [J]. CANCER LETTERS, 2012, 327 (1-2) : 48 - 60
  • [3] Altered microRNA expression profiles are involved in resistance to low-dose ionizing radiation in the absence of BMI1 in human dermal fibroblasts
    Bae, Seunghee
    Kim, Karam
    Cha, Hwa Jun
    Choi, Yeongmin
    Shin, Shang Hun
    An, In-Sook
    Lee, Jae Ho
    Song, Jie-Young
    Yang, Kwang Hee
    Nam, Seon Young
    An, Sungkwan
    [J]. INTERNATIONAL JOURNAL OF ONCOLOGY, 2014, 45 (04) : 1618 - 1628
  • [4] The European initiative on low-dose risk research: from the HLEG to MELODI
    Belli, Mauro
    Tabocchini, Maria Antonella
    Jourdain, Jean-Rene
    Salomaa, Sisko
    Repussard, Jacques
    [J]. RADIATION PROTECTION DOSIMETRY, 2015, 166 (1-4) : 178 - 181
  • [5] Cancer risks attributable to low doses of ionizing radiation: Assessing what we really know
    Brenner, DJ
    Doll, R
    Goodhead, DT
    Hall, EJ
    Land, CE
    Little, JB
    Lubin, JH
    Preston, DL
    Preston, RJ
    Puskin, JS
    Ron, E
    Sachs, RK
    Samet, JM
    Setlow, RB
    Zaider, M
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (24) : 13761 - 13766
  • [6] A Commentary on: "A History of the United States Department of Energy (DOE) Low Dose Radiation Research Program: 1998-2008''
    Brooks, Antone L.
    [J]. RADIATION RESEARCH, 2015, 183 (04) : 375 - 381
  • [7] What is hormesis and its relevance to healthy aging and longevity?
    Calabrese, Edward J.
    Dhawan, Gaurav
    Kapoor, Rachna
    Iavicoli, Ivo
    Calabrese, Vittorio
    [J]. BIOGERONTOLOGY, 2015, 16 (06) : 693 - 707
  • [8] Moderate dose rate ionizing radiation increases longevity
    Cameron, JR
    [J]. BRITISH JOURNAL OF RADIOLOGY, 2005, 78 (925) : 11 - 13
  • [9] Radiation increased the longevity of British radiologists
    Cameron, JR
    [J]. BRITISH JOURNAL OF RADIOLOGY, 2002, 75 (895) : 637 - 639
  • [10] Master of science (Msc) Program in radiation Biology: An interdepartmental course Bridging the Gap between radiation-related Preclinical and clinical Disciplines to Prepare Next-Generation Medical scientists
    Combs, Stephanie E.
    Kessel, Carmen
    Wilkens, Jan J.
    Multhoff, Gabriele
    Schmid, Thomas E.
    Vaupel, Peter
    Trott, Klaus-Ruediger
    Berberat, Pascal
    Atkinson, Michael J.
    [J]. FRONTIERS IN ONCOLOGY, 2017, 7