Recent advances in the synthesis and reactivity of spiro-epoxyoxindoles

被引：12

作者：

Monticelli, Serena ^{[1
]}

Castoldi, Laura ^{[1
]}

Touqeer, Saad ^{[1
]}

Miele, Margherita ^{[1
]}

Urban, Ernst ^{[1
]}

Pace, Vittorio ^{[1
]}

机构：

[1] Univ Vienna, Dept Pharmaceut Chem, 14 Althanstr, A-1090 Vienna, Austria

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2018年 / 54卷 / 04期

关键词：

epoxides; isatins; spiro compounds; Friedel-Crafts reaction; nucleophilic addition; CATALYTIC KINETIC RESOLUTION; FRIEDEL-CRAFTS ALKYLATION; ISATINS; ACCESS;

D O I：

10.1007/s10593-018-2280-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Spiro-epoxyoxindoles containing an unsubstituted methylene fragment in the oxirane ring are excellent building blocks in organic synthesis due to the high reactivity conferred by the three-membered oxygenated cycle. In this minireview, a concise survey of the methods of their synthesis and examples of reactivity with carbon and nitrogen nucleophiles is presented, with a particular focus on the stereochemical aspects. The review covers the literature for the last twenty years.

引用

页码：389 / 393

页数：5

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