Serotonin 1A receptors and sexual behavior in male rats: A review

被引：40

作者：

Snoeren, Eelke M. S. ^{[1
]}

Veening, Jan G. ^{[2
,3
,4
]}

Olivier, Berend ^{[2
,3
]}

Oosting, Ronald S. ^{[2
,3
]}

机构：

[1] Univ Tromso, Dept Psychol, N-9038 Tromso, Norway

[2] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Div Pharmacol, NL-3584 CG Utrecht, Netherlands

[3] Univ Utrecht, Rudolf Magnus Inst Neurosci, NL-3584 CG Utrecht, Netherlands

[4] Radboud Univ Nijmegen, Med Ctr, Dept Anat, NL-6525 ED Nijmegen, Netherlands

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 2014年 / 121卷

关键词：

Serotonin; 5-HT1A receptors; Sexual behavior; Male; Animal models; SUBPARAFASCICULAR THALAMIC NUCLEUS; DORSAL RAPHE NUCLEUS; MEDIAL PREOPTIC AREA; CENTRAL-NERVOUS-SYSTEM; LATERAL HYPOTHALAMIC AREA; LUMBAR SPINAL-CORD; MATING-INDUCED FOS; BACK MUSCLE EMG; 5-HT1A RECEPTOR; PARAVENTRICULAR NUCLEUS;

D O I：

10.1016/j.pbb.2013.11.007

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Serotonin plays an important role in male sexual behavior. Many studies have been performed on the pivotal role of 5-HT1A receptors in sexual behavior. Overall, 5-HT1A A receptors do not appear to be involved under normal circumstances, but become very important under conditions of elevated serotonin levels in sexual behavior. 5-HT1A receptor agonists facilitate ejaculatory behavior in male rats, while inhibiting copulatory behavior. Three different phases can be distinguished in rats' sexual cycle, the introductory (precopulatory), the copulatory and the executive (ejaculatory) phases. Different mechanisms and brain regions are involved in these phases. The mechanisms, brain regions and the possible involvement of 5-HT and 5-HT1A receptors in the appropriate phases in male rat sexual behavior will be discussed in the current review. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：102 / 114

页数：13

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