Etiology and Outcome of non-immune Hydrops Fetalis in Southern China: report of 1004 cases

被引：15

作者：

Meng, Dahua ^{[1
]}

Li, Qifei ^{[2
,3
,4
,5
]}

Hu, Xuehua ^{[6
]}

Wang, Lifang ^{[1
]}

Tan, Shuyin ^{[1
]}

Su, Jiasun ^{[7
,8
]}

Zhang, Yue ^{[7
,8
]}

Sun, Weijia ^{[7
,8
]}

Chen, Biyan ^{[7
,8
]}

He, Sheng ^{[7
,8
]}

Lin, Fei ^{[7
,8
]}

Xie, Bobo ^{[7
,8
]}

Chen, Shaoke ^{[7
,8
]}

Agrawal, Pankaj B. ^{[2
,3
,4
,5
]}

Luo, Shiyu ^{[7
,8
]}

Fu, Chunyun ^{[6
,7
,8
]}

机构：

[1] Maternal & Child Hlth Hosp Guangxi Zhuang Autonom, Dept Clin Genet, Nanning 530003, Peoples R China

[2] Boston Childrens Hosp, Div Newborn Med, Boston, MA 02115 USA

[3] Harvard Med Sch, Boston, MA 02115 USA

[4] Boston Childrens Hosp, Div Genet & Genom, Boston, MA 02115 USA

[5] Boston Childrens Hosp, Manton Ctr Orphan Dis Res, Boston, MA 02115 USA

[6] Maternal & Child Hlth Hosp Guangxi Zhuang Autonom, Med Sci Lab, Nanning 530003, Peoples R China

[7] Maternal & Child Hlth Hosp Guangxi Zhuang Autonom, Dept Genet Metab, Nanning 530003, Peoples R China

[8] Maternal & Child Hlth Hosp Guangxi Zhuang Autonom, Res Ctr Guangxi Birth Defects Control & Prevent, Nanning 530003, Peoples R China

来源：

SCIENTIFIC REPORTS | 2019年 / 9卷 / 1期

基金：

中国国家自然科学基金;

关键词：

PLACENTAL THICKNESS; GESTATIONAL-AGE; 2ND TRIMESTER; PREGNANCY; MUTATIONS;

D O I：

10.1038/s41598-019-47050-6

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Non-immune hydrops fetalis (NIHF) is a complex condition with a high mortality and morbidity rate. Here we report the etiology and outcome of 1004 fetuses with NIHF, in a large single Maternal and Children's hospital of Southern China, since the year of 2009 to 2016. Among these 1004 fetuses with NIHF, the etiology was identified prenatally in 722 of them (72%). The most common ones were hematologic diseases and chromosomal abnormalities. There were eight spontaneous abortions, 18 intrauterine fetal demise, 672 pregnancy terminations and 87 were lost to follow-up. 219 of the 1004 fetuses were live-born and the overall survival rate was 21.8% at this point. After birth 16 perinatal or early neonatal deaths were encountered and five lost to follow-up. Of the remaining 198 newborns, 153 thrived without apparent morbidity. The most significant factors associated with mortality were prematurity and low birthweight. In conclusion, we described the largest report of underlying causes and outcome of NIHF in Southern China. Etiologies were identified for 72% of 1004 fetuses with NIHF. And two poor prognostic factors for survival are preterm birth at less than 36.5 weeks and birthweight lower than 2575 g respectively.

引用

页数：6

共 26 条

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