Calcitriol and lexicalcitol (KH1060) inhibit the growth of human breast adenocarcinoma cells by enhancing transforming growth factor-beta production

被引：20

作者：

Mercier, T ^{[1
]}

Chaumontet, C ^{[1
]}

GaillardSanchez, I ^{[1
]}

Martel, P ^{[1
]}

Heberden, C ^{[1
]}

机构：

[1] INRA,CRJ,LAB NUTR & SCEURITE ALIMENTAIRE,F-78352 JOUY EN JOSAS,FRANCE

来源：

BIOCHEMICAL PHARMACOLOGY | 1996年 / 52卷 / 03期

关键词：

calcitriol; 1,25-dihydroxyvitamin-D-3; KH1060; TGF-beta; MCF-7; cells;

D O I：

10.1016/0006-2952(96)00254-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The mechanisms involved in the antiproliferative action of calcitriol (1 alpha,25(OH)(2)D-3) were investigated using human breast carcinoma epithelial cells (the MCF-7 cell line). Calcitriol and KH1060, a synthetic analog, inhibited cell growth in a time- and dose-dependent way. The substances similarly stimulated total TGF-beta secretion after 24 hours, and Northern blot analyses showed that mRNA levels for TGF-beta 1 were increased, as well. When MCF-7 cells were co-incubated with calcitriol and a neutralizing antiTGF-beta 1,beta 2,beta 3 antibody, growth inhibition was completely abrogated. With KH1060, the antibody could only partly block growth inhibition. This study shows that TCF-beta is involved in the growth response to calcitriol and KH1060 in MCF-7 cells.

引用

页码：505 / 510

页数：6

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