CEACAM1 loss links inflammation to insulin resistance in obesity and non-alcoholic steatohepatitis (NASH)

被引：37
|
作者：
Najjar, Sonia M. [1 ,2 ]
Russo, Lucia [1 ,2 ]
机构：
[1] Univ Toledo, Ctr Diabet & Endocrine Res, Toledo, OH 43614 USA
[2] Univ Toledo, Coll Med & Life Sci, Dept Physiol & Pharmacol, Toledo, OH 43614 USA
来源：
SEMINARS IN IMMUNOPATHOLOGY | 2014年 / 36卷 / 01期
关键词：
CEACAM1; Insulin resistance; Adipokines; Metabolic syndrome; NASH; FATTY-LIVER-DISEASE; TUMOR-NECROSIS-FACTOR; CELL-ADHESION MOLECULE-1; KILLER T-CELLS; INDUCED OXIDATIVE STRESS; ENDOPLASMIC-RETICULUM STRESS; COLONY-STIMULATING FACTOR; INDUCED HEPATIC STEATOSIS; RECEPTOR TYROSINE KINASE; KAPPA-B ACTIVATION;
D O I：
10.1007/s00281-013-0407-3
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Mounting epidemiological evidence points to an association between metabolic syndrome and non-alcoholic steatohepatitis (NASH), an increasingly recognized new epidemic. NASH pathologies include hepatocellular ballooning, lobular inflammation, hepatocellular injury, apoptosis, and hepatic fibrosis. We will review the relationship between insulin resistance and inflammation in visceral obesity and NASH in an attempt to shed more light on the pathogenesis of these major metabolic diseases. Moreover, we will identify loss of the carcinoembryonic antigen-related cell adhesion molecule 1 as a unifying mechanism linking the immunological and metabolic abnormalities in NASH.
引用
收藏
页码：55 / 71
页数：17
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