Kuguacins F-S, cucurbitane triterpenoids from Momordica charantia

被引：70

作者：

Chen, Jian-Chao ^{[1
]}

Liu, Wu-Qing ^{[2
]}

Lu, Lu ^{[1
,3
]}

Qju, Ming-Hua ^{[1
]}

Zheng, Yong-Tang ^{[2
]}

Yang, Liu-Meng ^{[2
]}

Zhang, Xian-Min ^{[1
]}

Zhou, Lin ^{[1
]}

Li, Zhong-Rong ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Botany, Kunming 650204, Yunnan, Peoples R China

[2] Chinese Acad Sci, Lab Mol Immunopharmacol, Key Lab Animal Models & Human Dis Mech, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China

[3] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

来源：

PHYTOCHEMISTRY | 2009年 / 70卷 / 01期

关键词：

Momordica charantia; Cucurbitaceae; Cucurbitane triterpenoids; Kuguacins F-S; IMMATURE FRUITS; GLYCOSIDES; CONSTITUENTS; OCTANORCUCURBITANE; LEAVES;

D O I：

10.1016/j.phytochem.2008.10.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chemical investigation of the vines and leaves of Momordica charantia resulted in isolation of fourteen cucurbitane triterpenoids, kuguacins F-S (1-14), including two pentanorcucurbitacins (6 and 7), one octanorcucurbitacin (8), and two trinorcucurbitacins (11 and 12), along with six known analogues. Their structures were elucidated on the basis of extensive spectroscopic and single-crystal X-ray diffraction analyses. Compounds 1-14 exhibited weak anti-HIV-1 activities in vitro. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：133 / 140

页数：8

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