Protective role of anticancer drugs in neurodegenerative disorders: A drug repurposing approach

被引：16

作者：

Advani, Dia ^{[1
]}

Gupta, Rohan ^{[1
]}

Tripathi, Rahul ^{[1
]}

Sharma, Sudhanshu ^{[1
]}

Ambasta, Rashmi K. ^{[1
]}

Kumar, Pravir ^{[1
,2
,3
,4
]}

机构：

[1] Dept Biotechnol, Mol Neurosci & Funct Genom Lab, Room FW4TF3,Mech Engn Bldg,Bawana Rd, Delhi 110042, India

[2] Delhi Technol Univ, Delhi, India

[3] Delhi Coll Engn, Delhi, India

[4] Tufts Univ, Sch Med, Boston, MA 02111 USA

来源：

NEUROCHEMISTRY INTERNATIONAL | 2020年 / 140卷

关键词：

Anticancer drugs; Neurodegenerative disorders; Drug repurposing; Kinase inhibitors; Neurotoxins; AMYOTROPHIC-LATERAL-SCLEROSIS; PROLYL ISOMERASE PIN1; SQUAMOUS-CELL CARCINOMA; PROTEIN PHOSPHATASE 2A; AMYLOID-BETA-PEPTIDE; A-ALPHA SUBUNIT; ALZHEIMERS-DISEASE; MULTIPLE-SCLEROSIS; NITRIC-OXIDE; OXIDATIVE STRESS;

D O I：

10.1016/j.neuint.2020.104841

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The disease heterogeneity and little therapeutic progress in neurodegenerative diseases justify the need for novel and effective drug discovery approaches. Drug repurposing is an emerging approach that reinvigorates the classical drug discovery method by divulging new therapeutic uses of existing drugs. The common biological background and inverse tuning between cancer and neurodegeneration give weight to the conceptualization of repurposing of anticancer drugs as novel therapeutics. Many studies are available in the literature, which highlights the success story of anticancer drugs as repurposed therapeutics. Among them, kinase inhibitors, developed for various oncology indications evinced notable neuroprotective effects in neurodegenerative diseases. In this review, we shed light on the salient role of multiple protein kinases in neurodegenerative disorders. We also proposed a feasible explanation of the action of kinase inhibitors in neurodegenerative disorders with more attention towards neurodegenerative disorders. The problem of neurotoxicity associated with some anticancer drugs is also highlighted. Our review encourages further research to better encode the hidden potential of anticancer drugs with the aim of developing prospective repurposed drugs with no toxicity for neurodegenerative disorders.

引用

页数：25

共 370 条

[1] p38α stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis [J].