Vitamin D sufficiency associates with an increase in anti-inflammatory cytokines after intense exercise in humans

被引：32

作者：

Barker, Tyler ^{[1
]}

Martins, Thomas B. ^{[2
]}

Hill, Harry R. ^{[2
,3
]}

Kjeldsberg, Carl R. ^{[2
,3
]}

Dixon, Brian M. ^{[4
]}

Schneider, Erik D. ^{[4
]}

Henriksen, Vanessa T. ^{[1
]}

Weaver, Lindell K. ^{[5
,6
,7
]}

机构：

[1] Orthoped Specialty Hosp, Murray, UT 84107 USA

[2] Inst Clin & Expt Pathol, ARUP Labs, Salt Lake City, UT 84108 USA

[3] Univ Utah, Dept Pathol, Salt Lake City, UT 84132 USA

[4] USANA Hlth Sci Inc, Salt Lake City, UT 84120 USA

[5] Intermt Med Ctr, Murray, UT 84107 USA

[6] Latter Day St Hosp, Salt Lake City, UT 84143 USA

[7] Univ Utah, Sch Med, Salt Lake City, UT 84132 USA

来源：

CYTOKINE | 2014年 / 65卷 / 02期

关键词：

Vitamin D; Cytokines; Skeletal muscle strength; SKELETAL-MUSCLE STRENGTH; 25-HYDROXYVITAMIN D; DOUBLE-BLIND; RESPONSES; ADULTS;

D O I：

10.1016/j.cyto.2013.12.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The purpose of this study was to identify the influence of vitamin D status (insufficient vs. sufficient) on circulating cytokines and skeletal muscle strength after muscular injury. To induce muscular injury, one randomly selected leg (SSC) performed exercise consisting of repetitive eccentric-concentric contractions. The other leg served as the control. An averaged serum 25(OH)D concentration from two blood samples collected before exercise and on separate occasions was used to establish vitamin D insufficiency (<30 ng/mL, n = 6) and sufficiency (>30 ng/mL, n = 7) in young, adult males. Serum cytokine concentrations, single-leg peak isometric force, and single-leg peak power output were measured before and during the days following the exercise protocol. The serum IL-10 and IL-13 responses to muscular injury were significantly (both p < 0.05) increased in the vitamin D sufficient group. The immediate and persistent (days) peak isometric force (p < 0.05) and peak power output (p < 0.05) deficits in the SSC leg after the exercise protocol were not ameliorated with vitamin D sufficiency. We conclude that vitamin D sufficiency increases the anti-inflammatory cytokine response to muscular injury. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：134 / 137

页数：4

共 13 条

[1] Circulating pro-inflammatory cytokines are elevated and peak power output correlates with 25-hydroxyvitamin D in vitamin D insufficient adults [J].