CyberKnife stereotactic radiotherapy for isolated recurrence in the prostatic bed

被引：28

作者：

Detti, B. ^{[1
]}

Bonomo, P. ^{[1
]}

Masi, L. ^{[2
]}

Doro, R. ^{[2
]}

Cipressi, S. ^{[2
]}

Iermano, C. ^{[2
]}

Bonucci, I. ^{[2
]}

Franceschini, D. ^{[1
]}

Di Brina, L. ^{[1
]}

Baki, M. ^{[1
]}

Simontacchi, G. ^{[1
]}

Meattini, I. ^{[1
]}

Carini, M. ^{[3
]}

Serni, S. ^{[3
]}

Nicita, G. ^{[3
]}

Livi, L. ^{[1
]}

机构：

[1] Univ Florence, Azienda Osped Univ Careggi, Radiotherapy Unit, Largo GA Brambilla 3, Florence, Italy

[2] Univ Florence, CyberKnife Ctr, IFCA, Florence, Italy

[3] Univ Florence, Dept Expt & Clin Med, Urol Unit, Florence, Italy

来源：

WORLD JOURNAL OF UROLOGY | 2016年 / 34卷 / 03期

关键词：

Prostate cancer; Stereotactic radiotherapy; CyberKnife; Local control; Relapse; RADICAL RETROPUBIC PROSTATECTOMY; SALVAGE RADIOTHERAPY; RADIATION-THERAPY; ALPHA/BETA-RATIO; CANCER; BRACHYTHERAPY; ADJUVANT; POSTPROSTATECTOMY;

D O I：

10.1007/s00345-015-1613-5

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose To report a clinical experience of stereotactic body radiation therapy (SBRT) for isolated recurrence in the prostatic bed from prostate cancer. Materials and methods Between November 2011 and November 2013, 16 patients were treated with SBRT for a macroscopic isolated recurrence of prostate cancer in the prostatic bed. All patients were initially treated with radical prostatectomy, and half of them also received radiotherapy. Two schedules of SBRT were used: 30 Gy in 5 fractions in previously irradiated patients, 35 Gy in five fractions in radiotherapy-naive patients. Results At a median follow-up of 10 months (range 2-21 months), a significant biochemical response was found in all but one patient. At imaging evaluation, no local progression was noted: 10 patients showed partial response while four stable disease. At the moment of analysis, all 16 patients were alive. Seven of them experienced distant relapse, while nine maintained biochemical control, with no further therapy. Median time to relapse was 9.3 months (range 3-15.2 months). The treatment was well tolerated: One patient experienced G2 acute genitourinary and gastrointestinal toxicity. Conclusions Our experience shows that SBRT with CyberKnife for isolated nodal relapse is a safe and well-tolerated treatment.

引用

页码：311 / 317

页数：7

共 24 条

[1] Review and Uses of Stereotactic Body Radiation Therapy for Oligometastases [J].