Terretonins E and F, Inhibitors of the Mitochondrial Respiratory Chain from the Marine-Derived Fungus Aspergillus insuetus

被引:47
|
作者
Pilar Lopez-Gresa, M. [1 ]
Cabedo, Nuria [2 ]
Carmen Gonzalez-Mas, M. [3 ]
Ciavatta, Maria Letizia [4 ]
Avila, Conxita [5 ]
Primo, Jaime [2 ]
机构
[1] CSIC UPV, IBMCP, Valencia 46022, Spain
[2] Univ Politecn Valencia, CEQA, Valencia 46022, Spain
[3] Fdn Agroalimed, IVIA, Ctr Citricultura, Valencia 46113, Spain
[4] CNR, ICB, I-80078 Pozzuoli, Italy
[5] Univ Barcelona, Fac Biol, Dept Biol Anim Invertebrats, E-08028 Barcelona, Spain
来源
JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 07期
关键词
COMPLEX-I; ABSOLUTE-CONFIGURATIONS; MOSHER METHOD; STRAIN; ACETOGENINS; DERIVATIVES; CITREOHYBRIDONES; INSECTICIDES; METABOLITES; DITERPENES;
D O I
10.1021/np900085n
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Two new meroterpenoids, terretonins E and F (1, 2), together with three known compounds, aurantiamine (3), linoleic acid, and uridine, were isolated as fermentation products of the marine-derived fungus Aspergillus insuetus, which was associated with the sponge Petrosia ficiformis. Structures of all isolates were elucidated employing spectroscopic methods, mainly by two-dimensional NMR techniques. Compounds 1-3 showed activity as inhibitors of the mammalian mitochondrial respiratory chain.
引用
收藏
页码:1348 / 1351
页数:4
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