Terretonins E and F, Inhibitors of the Mitochondrial Respiratory Chain from the Marine-Derived Fungus Aspergillus insuetus

被引：47

作者：

Pilar Lopez-Gresa, M. ^{[1
]}

Cabedo, Nuria ^{[2
]}

Carmen Gonzalez-Mas, M. ^{[3
]}

Ciavatta, Maria Letizia ^{[4
]}

Avila, Conxita ^{[5
]}

Primo, Jaime ^{[2
]}

机构：

[1] CSIC UPV, IBMCP, Valencia 46022, Spain

[2] Univ Politecn Valencia, CEQA, Valencia 46022, Spain

[3] Fdn Agroalimed, IVIA, Ctr Citricultura, Valencia 46113, Spain

[4] CNR, ICB, I-80078 Pozzuoli, Italy

[5] Univ Barcelona, Fac Biol, Dept Biol Anim Invertebrats, E-08028 Barcelona, Spain

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 07期

关键词：

COMPLEX-I; ABSOLUTE-CONFIGURATIONS; MOSHER METHOD; STRAIN; ACETOGENINS; DERIVATIVES; CITREOHYBRIDONES; INSECTICIDES; METABOLITES; DITERPENES;

D O I：

10.1021/np900085n

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new meroterpenoids, terretonins E and F (1, 2), together with three known compounds, aurantiamine (3), linoleic acid, and uridine, were isolated as fermentation products of the marine-derived fungus Aspergillus insuetus, which was associated with the sponge Petrosia ficiformis. Structures of all isolates were elucidated employing spectroscopic methods, mainly by two-dimensional NMR techniques. Compounds 1-3 showed activity as inhibitors of the mammalian mitochondrial respiratory chain.

引用

页码：1348 / 1351

页数：4

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