Synthesis of Dimeric Quinazolin-2-one, 1,4-Benzodiazepin-2-one, and Isoalloxazine Compounds as Inhibitors of Amyloid Peptides Association

被引：10

作者：

Barthel, Alexander

Trieschmann, Lothar ^{[2
]}

Stroehl, Dieter

Kluge, Ralph

Boehm, Gerald ^{[3
]}

Csuk, Rene ^{[1
]}

机构：

[1] Univ Halle Wittenberg, Bereich Organ Chem, D-06120 Halle, Saale, Germany

[2] Scil Prot Prod GmbH, Halle, Saale, Germany

[3] IGZ BioMed ZmK Wurzburg, Wurzburg, Germany

来源：

ARCHIV DER PHARMAZIE | 2009年 / 342卷 / 08期

关键词：

Anti-Alzheimer; Antiprion; 1,4-Benzodiazepin-2-one; Isoalloxazine; Quinazolin-2-one; RIBOFLAVIN;

D O I：

10.1002/ardp.200800196

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of dimeric compounds derived from quinazolin-2-one and 1,4-benzodiazepin-2-one possessing a piperazine or homopiperazine spacer was investigated. In addition, a piperazine spacered bis-isoalloxazine and a bis-riboflavin compound were prepared and their ability to interrupt the association of prion proteins and Alzheimer-specific A beta peptides was investigated using a fast screening system based on flow cytometry. The bis-isoalloxazine 14 was identified as a new lead structure.

引用

页码：445 / 452

页数：8

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