Influence of Propylthiouracil and Methimazole Pre-treatment on the Outcome of Iodine-131 Therapy in Hyperthyroid Patients with Graves' Disease

被引：8
|
作者：
Shi, G-M [1 ]
Xu, Q. [2 ]
Zhu, C-Y [2 ]
Yang, Y-L [2 ]
机构：
[1] Zhejiang Univ, Coll Med, Affiliated Hosp 1, Dept Chemotherapy, Hangzhou 310003, Zhejiang, Peoples R China
[2] Zhejiang Univ, Coll Med, Affiliated Hosp 1, Dept Nucl Med, Hangzhou 310003, Zhejiang, Peoples R China
来源：
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2009年 / 37卷 / 02期
关键词：
GRAVES' DISEASE; HYPERTHYROIDISM; PROPYLTHIOURACIL; METHIMAZOLE; (131)I THERAPY; RADIOACTIVE IODINE THERAPY; RANDOMIZED CLINICAL-TRIAL; RADIOIODINE THERAPY; ANTITHYROID DRUGS; CURE RATES; EFFICACY;
D O I：
10.1177/147323000903700235
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
There is ongoing controversy about potential differences in the influence of the anti-thyroid drugs propylthiouracil (PTU) and methimazole (MMI) on radioiodine treatment of Graves' hyperthyroidism. This retrospective study investigated the influence of PTU and MMI pre-treatment, individually or sequentially, on the outcome of iodine-131 ((131)I) therapy in 199 patients with Graves' disease who had been treated with (131)I for the first time and followed up at 3 and 6 months after treatment. Pre-treatment with PTU, or sequential PTU and MMI pretreatment, increased the failure rate of (131)I therapy and reduced the rate of hypothyroidism. MMI pre-treatment alone had no significant influence on the results of (131)I therapy. Logistic regression analyses indicated that PTU pre-treatment and having a thyroid gland of > 60 g were both significantly related to (131)I therapy failure.
引用
收藏
页码：576 / 582
页数：7
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