Influence of Propylthiouracil and Methimazole Pre-treatment on the Outcome of Iodine-131 Therapy in Hyperthyroid Patients with Graves' Disease

被引：9
作者：
Shi, G-M [1 ]
Xu, Q. [2 ]
Zhu, C-Y [2 ]
Yang, Y-L [2 ]
机构：
[1] Zhejiang Univ, Coll Med, Affiliated Hosp 1, Dept Chemotherapy, Hangzhou 310003, Zhejiang, Peoples R China
[2] Zhejiang Univ, Coll Med, Affiliated Hosp 1, Dept Nucl Med, Hangzhou 310003, Zhejiang, Peoples R China
来源：
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2009年 / 37卷 / 02期
关键词：
GRAVES' DISEASE; HYPERTHYROIDISM; PROPYLTHIOURACIL; METHIMAZOLE; (131)I THERAPY; RADIOACTIVE IODINE THERAPY; RANDOMIZED CLINICAL-TRIAL; RADIOIODINE THERAPY; ANTITHYROID DRUGS; CURE RATES; EFFICACY;
D O I：
10.1177/147323000903700235
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
There is ongoing controversy about potential differences in the influence of the anti-thyroid drugs propylthiouracil (PTU) and methimazole (MMI) on radioiodine treatment of Graves' hyperthyroidism. This retrospective study investigated the influence of PTU and MMI pre-treatment, individually or sequentially, on the outcome of iodine-131 ((131)I) therapy in 199 patients with Graves' disease who had been treated with (131)I for the first time and followed up at 3 and 6 months after treatment. Pre-treatment with PTU, or sequential PTU and MMI pretreatment, increased the failure rate of (131)I therapy and reduced the rate of hypothyroidism. MMI pre-treatment alone had no significant influence on the results of (131)I therapy. Logistic regression analyses indicated that PTU pre-treatment and having a thyroid gland of > 60 g were both significantly related to (131)I therapy failure.
引用
收藏
页码：576 / 582
页数：7
相关论文
共 20 条
[1]   Age and gender predict the outcome of treatment for Graves' hyperthyroidism [J].
Allahabadia, A ;
Daykin, J ;
Holder, RL ;
Sheppard, MC ;
Gough, SCL ;
Franklyn, JA .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (03) :1038-1042
[2]   The effect of methimazole pretreatment on the efficacy of radioactive iodine therapy in Graves' hyperthyroidism: One-year follow-up of a prospective, randomized study [J].
Andrade, VA ;
Gross, JL ;
Maia, AL .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (08) :3488-3493
[3]   Propylthiouracil before 131I therapy of hyperthyroid diseases:: Effect on cure rate evaluated by a randomized clinical trial [J].
Bonnema, SJ ;
Bennedbæk, FN ;
Veje, A ;
Marving, J ;
Hegedüs, L .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (09) :4439-4444
[4]   Continuous methimazole therapy and its effect on the cure rate of hyperthyroidism using radioactive iodine:: An evaluation by a randomized trial [J].
Bonnema, Steen Joop ;
Bennedbaek, Finn Noe ;
Veje, Annegrete ;
Marving, Jens ;
Hegedus, Laszlo .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (08) :2946-2951
[5]   The effect of methimazole on cure rates after radioiodine treatment for Graves' hyperthyroidism: A randomized clinical trial [J].
Braga, M ;
Walpert, N ;
Burch, HB ;
Solomon, BL ;
Cooper, DS .
THYROID, 2002, 12 (02) :135-139
[6]   Thyroid status, cardiovascular risk, and mortality in older adults [J].
Cappola, AR ;
Fried, LP ;
Arnold, AM ;
Danese, MD ;
Kuller, LH ;
Burke, GL ;
Tracy, RP ;
Ladenson, PW .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2006, 295 (09) :1033-1041
[7]   Drug therapy: Antithyroid drugs [J].
Cooper, DS .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (09) :905-917
[8]  
FRANKLYN JA, 1994, NEW ENGL J MED, V330, P1731
[9]   The effect of propylthiouracil on subsequent radioactive iodine therapy in Graves' disease [J].
Hancock, LD ;
Tuttle, RM ;
LeMar, H ;
Bauman, J ;
Patience, T .
CLINICAL ENDOCRINOLOGY, 1997, 47 (04) :425-430
[10]   Pretreatment with propylthiouracil but not methimazole reduces the therapeutic efficacy of iodine-131 in hyperthyroidism [J].
Imseis, RE ;
Vanmiddlesworth, L ;
Massie, JD ;
Bush, AJ ;
Vanmiddlesworth, NR .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1998, 83 (02) :685-687
12