Interaction between an ADCY3 Genetic Variant and Two Weight-Lowering Diets Affecting Body Fatness and Body Composition Outcomes Depending on Macronutrient Distribution: A Randomized Trial

被引:24
作者
Goni, Leticia [1 ,2 ]
Ignacio Riezu-Boj, Jose [1 ,2 ,3 ]
Milagro, Fermin I. [1 ,2 ,3 ,4 ]
Corrales, Fernando J. [5 ,6 ]
Ortiz, Lourdes [7 ]
Cuervo, Marta [1 ,2 ,3 ,4 ]
Alfredo Martinez, J. [1 ,2 ,3 ,4 ,8 ]
机构
[1] Univ Navarra, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain
[2] Univ Navarra, Ctr Nutr Res, Pamplona 31008, Spain
[3] Navarra Inst Hlth Res IdiSNA, Pamplona 31008, Spain
[4] Inst Hlth Carlos III, Biomed Res Ctr Network Physiopathol Obes & Nutr C, Madrid 28029, Spain
[5] CSIC, CNB, E-28049 Madrid, Spain
[6] Inst Hlth Carlos III, Biomed Res Ctr Network Hepat & Gastrointestinal D, Madrid 28029, Spain
[7] Univ Navarra, Ctr Appl Med Res CIMA, Genom Core Facil, Pamplona 31008, Spain
[8] Res Inst Food & Hlth Sci IMDEA Food, Madrid 28049, Spain
关键词
ADCY3; gene-diet interaction; energy restricted diet; body fatness; body composition; MASS INDEX; CYCLASE; 3; LOCI; INDIVIDUALS; INSIGHTS; ISLETS;
D O I
10.3390/nu10060789
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The adenylate cyclase 3 (ADCY3) gene is involved in the regulation of several metabolic processes including the development and function of adipose tissue. The effects of the ADCY3 rs10182181 genetic variant on changes in body composition depending on the macronutrient distribution intake after 16 weeks of the dietary intervention were tested. The ADCY3 genetic variant was genotyped in 147 overweight or obese subjects, who were randomly assigned to one of the two diets varying in macronutrient content: a moderately-high-protein diet and a low-fat diet. Anthropometric and body composition measurements (DEXA scan) were recorded. Significant interactions between the ADCY3 genotype and dietary intervention on changes in weight, waist circumference, and body composition were found after adjustment for covariates. Thus, in the moderately-high-protein diet group, the G allele was associated with a lower decrease of fat mass, trunk and android fat, and a greater decrease in lean mass. Conversely, in the low-fat diet group carrying the G allele was associated with a greater decrease in trunk, android, gynoid, and visceral fat. Subjects carrying the G allele of the rs10182181 polymorphism may benefit more in terms of weight loss and improvement of body composition measurements when undertaking a hypocaloric low-fat diet as compared to a moderately-high-protein diet.
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页数:10
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