The effects of local application of D2 selective dopaminergic drugs into the medial prefrontal cortex of rats in a delayed spatial choice task

被引:51
作者
Druzin, MY
Kurzina, NP
Malinina, EP
Kozlov, AP
机构
[1] Inst Expt Med, Pavlov Physiol Dept, St Petersburg 197376, Russia
[2] St Petersburg State Univ, Ukhtomsky Physiol Inst, Dept Psychophysiol, St Petersburg 199034, Russia
关键词
delayed spatial choice; medial prefrontal cortex; working memory; proactive interference; dopamine D2 receptor; rat;
D O I
10.1016/S0166-4328(99)00166-7
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The study examined the effects of modulation of dopamine D2 receptors-mediated neurotransmission in the rat's prefrontal cortex (PFC) on storage and executive components of working memory. Rats were trained on delayed (delay interval, 3 s) and non-delayed choice in a U-maze. The prominence of proactive interference was evaluated by sorting errors in a current trial on the basis of animal reactions in a preceding trial. The erroneous runs to the same arm of the maze as in the previous trial were identified as the repetitions (RE) and the erroneous runs to the other arm in comparison with the previous trial were classified as alternations (AE). The bilateral microinfusion of D2 agonists PPHT (0.004 mu g, 0.04 mu g, 0.4 mu g/l mu l) into medial wall of the PFC produced a dose-dependent increase in the error rate of the delayed-response task and did not influence non-delayed choice. In delay condition PPHT enhanced the perseverative tendencies (the rate of RE was significantly higher than the rate of AE), in non-delayed choice the erroneous performance was mainly represented by AE. In contrast, the infusion of D2-receptor antagonist sulpiride (0.03 mu g, 0.3 mu g, 3 mu g/l mu l) increased the accuracy of delayed choice and changed the mode of intertrial dependence-rats made significantly more AE than RE. The results are discussed in terms of the involvement of D2 receptor dependent transmission of the PFC in different cognitive processes related to the delayed performance in U-maze (within-trial short-term storage of information versus dynamic control of between-trials working memory processing). (C) 2000 Elsevier Science Ireland Ltd. Ail rights reserved.
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页码:99 / 111
页数:13
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