Synthesis and study of the structure-antitumor activity relationship of new pyridoxine-containing structural analogs of saccharumoside-B

被引：2
作者：
Pugachev, M. V. [1 ]
Agafonova, M. N. [1 ]
Gnezdilov, O. I. [2 ]
Badeev, Yu. V. [1 ]
Romanova, E. I. [1 ]
Nikishova, T. V. [1 ]
Balakin, K. V. [1 ]
Shtyrlin, Yu. G. [1 ]
机构：
[1] Kazan Volga Reg Fed Univ, 18 Ul Kremlevskaya, Kazan 420008, Russia
[2] Russian Acad Sci, Zavoisky Phys Tech Inst, Subdiv Fed Res Ctr, Kazan Sci Ctr, 10-7 Ul Sibirskiy trakt, Kazan 420029, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2022年 / 71卷 / 11期
关键词：
drug development; pyridoxine; saccharumoside-B; antitumor activity; cytotoxicity; GLYCOSIDES;
D O I：
10.1007/s11172-022-3669-x
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We synthesized a number of new derivatives of phenolic glycoside saccharumoside-B based on pyridoxine and 3-hydroxy-2-methylpyridine and studied their cytotoxicity in vitro against three normal (HEK-293, Chang Liver, MSC) and nine tumor (MCF-7, MDA-MB-231, A-498, SNB-19, M-14, NCI-H322M, HCT-115, HCT-116, PC-3) human cell lines compared with camptothecin, doxorubicin, and saccharumoside-B. The effect of the peripheral fragments of phenolic glycoside on the target activity was studied and the structure-antitumor activity relationship was established. A new efficient approach to the synthesis of saccharumoside-B was proposed.
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收藏
页码：2416 / 2425
页数：10
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