We report the most notable pharmacokinetic and pharmacodynamic characteristics of the antiepileptic drugs commercialised in the last four years (eslicarbazepine acetate, brivaracetam and perampanel). Their efficacy and safety are analysed in open-label clinical trials, which are the ones that reproduce their use in everyday life, without the rigid protocols used in clinical trials.
机构:
Yonsei Univ, Coll Med, Dept Neurol, Seoul, South Korea
Yonsei Univ, Coll Med, Epilepsy Res Inst, Seoul, South KoreaYonsei Univ, Coll Med, Dept Neurol, Seoul, South Korea
Heo, Kyoung
JOURNAL OF THE KOREAN MEDICAL ASSOCIATION,
2012,
55
(02):
: 155
-
173
机构:
Hebrew Univ Jerusalem, Fac Med, Sch Pharm, Inst Drug Res, Jerusalem, IsraelHebrew Univ Jerusalem, Fac Med, Sch Pharm, Inst Drug Res, Jerusalem, Israel