Dmoesin controls actin-based cell shape and polarity during Drosophila melanogaster oogenesis

被引：112

作者：

Polesello, C ^{[1
]}

Delon, I ^{[1
]}

Valenti, P ^{[1
]}

Ferrer, P ^{[1
]}

Payre, F ^{[1
]}

机构：

[1] CNRS, UMR 5547, Ctr Dev Biol, F-31062 Toulouse 4, France

来源：

NATURE CELL BIOLOGY | 2002年 / 4卷 / 10期

关键词：

D O I：

10.1038/ncb856

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ezrin, Radixin and Moesin (ERM) proteins are thought to constitute a bridge between the actin cytoskeleton and the plasma membrane (PM). Here we report a genetic analysis of Dmoesin, the sole member of the ERM family in Drosophila. We show that Dmoesin is required during oogenesis for anchoring microfilaments to the oocyte cortex. Alteration of the actin cytoskeleton resulting from Dmoesin mutations impairs the localization of maternal determinants, thus disrupting antero-posterior polarity. This study also demonstrates the requirement of Dmoesin for the specific organization of cortical microfilaments in nurse cells and, consequently, mutations in Dmoesin produce severe defects in cell shape.

引用

页码：782 / 789

页数：8

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