A two-dimensional thin Co-MOF nanosheet as a nanozyme with high oxidase-like activity for GSH detection

被引:30
|
作者
Han, Miaomiao [1 ]
Ren, Mengzhen [1 ]
Li, Zhaohui [1 ]
Qu, Lingbo [1 ]
Yu, Lanlan [1 ]
机构
[1] Zhengzhou Univ, Coll Chem, Zhengzhou Key Lab Funct Nanomat & Med Theranost, Zhengzhou 450001, Peoples R China
基金
中国国家自然科学基金;
关键词
PEROXIDASE-LIKE ACTIVITY; ELECTROCHEMICAL DETECTION; IRON;
D O I
10.1039/d2nj00876a
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Nanozymes with the advantages of excellent enzyme-mimicking activity, low cost and high stability have displayed great application potential in diverse fields as replacements for natural enzymes. In this study, a new nanozyme based on an ultrathin two-dimensional metal-organic framework nanomaterial D-ZIF-67 was prepared and characterized. D-ZIF-67 exhibited remarkable oxidase-like activity, which was attributed to the large specific surface area of the two-dimensional sheet structure, as well as its numerous exposed active sites compared with crystal MOFs. In the catalytic process of D-ZIF-67, the hydroxyl radical and superoxide anion played an essential role and facilitated the oxidation of the substrate 3,3 ',5,5 '-tetramethylbenzidine (TMB) by oxygen. The reducing agent glutathione (GSH) inhibited the catalytic activity of D-ZIF-67 besides reducing the oxidized oxTMB, based on which a simple, sensitive and accurate colorimetric method was developed to determine GSH, with the detection limit of 229.2 nM. This work mainly proposes a new two-dimensional metal-organic framework with high oxidase-like activity and provides a simple and practical platform for visual GSH detection by naked eyes.
引用
收藏
页码:10682 / 10689
页数:8
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