Metastasis-Free Interval Is Closely Related to Tumor Characteristics and Has Prognostic Value in Breast Cancer Patients with Distant Relapse
被引:14
作者:
Kim, Hee Jun
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Coll Med, Gangnam Severance Hosp, Dept Surg,Gangnam Med Res Ctr, Seoul 06273, South KoreaYonsei Univ, Coll Med, Gangnam Severance Hosp, Dept Surg,Gangnam Med Res Ctr, Seoul 06273, South Korea
Kim, Hee Jun
[1
]
Ahn, Sung Gwe
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Coll Med, Gangnam Severance Hosp, Dept Surg,Gangnam Med Res Ctr, Seoul 06273, South KoreaYonsei Univ, Coll Med, Gangnam Severance Hosp, Dept Surg,Gangnam Med Res Ctr, Seoul 06273, South Korea
Ahn, Sung Gwe
[1
]
Lee, Hak Min
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Coll Med, Gangnam Severance Hosp, Dept Surg,Gangnam Med Res Ctr, Seoul 06273, South KoreaYonsei Univ, Coll Med, Gangnam Severance Hosp, Dept Surg,Gangnam Med Res Ctr, Seoul 06273, South Korea
Lee, Hak Min
[1
]
论文数: 引用数:
h-index:
机构:
Park, Jong Tae
[1
]
论文数: 引用数:
h-index:
机构:
Han, Kyunghwa
[2
]
论文数: 引用数:
h-index:
机构:
Lee, Seung Ah
[3
]
Jeong, Joon
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Coll Med, Gangnam Severance Hosp, Dept Surg,Gangnam Med Res Ctr, Seoul 06273, South KoreaYonsei Univ, Coll Med, Gangnam Severance Hosp, Dept Surg,Gangnam Med Res Ctr, Seoul 06273, South Korea
Jeong, Joon
[1
]
机构:
[1] Yonsei Univ, Coll Med, Gangnam Severance Hosp, Dept Surg,Gangnam Med Res Ctr, Seoul 06273, South Korea
[2] Yonsei Univ, Coll Med, Gangnam Severance Hosp, Biostat Collaborat Unit,Gangnam Med Res Ctr, Seoul 06273, South Korea
[3] CHA Univ, CHA Bundang Med Ctr, Dept Surg, Songnam, South Korea
Breast neoplasms;
Metastasis;
Prognostic factor;
Subtypes;
BONE METASTASES;
RECURRENCE;
SURVIVAL;
HAZARD;
CARCINOMA;
MODELS;
TIME;
D O I:
10.4048/jbc.2015.18.4.371
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Purpose: We investigated the relationships between metastasis-free interval (MFI) and tumor characteristics, and assessed the prognostic value of MFI for survival after metastasis in patients with metastatic breast cancer. Furthermore, we compared MFI among the subtypes. Methods: We identified 335 patients with postoperative tumor recurrence at distant site(s). All patients underwent curative resection and had a MFI of at least 6 months. MFI was categorized as short (<2 years), intermediate 2 years and <5 years), or long (>= 5 years). Overall survival after metastasis (OSM) was estimated. Results: Patients with a shorter MFI were younger, more likely to have initial metastasis to visceral organs, and had a larger tumor with a higher stage and grade as well as a higher rate of nodal involvement at initial diagnosis. Among 136 patients with known disease subtypes, shorter MFI was associated with the triple-negative subtype while longer MFI was associated with the hormone receptor-positive/human epidermal growth factor receptor 2 negative subtype. Mortality after metastasis declined sharply with increasing MFI up to approximately 2 years, and continued gradually declining between 2 and 5 years. An MFI longer than 5 years did not add any survival benefit. MFI was a significant prognostic factor for OSM independent of nodal status, stage, metastatic site, and hormone receptor status of the metastasized cancer. Conclusion: MFI is closely related to biological characteristics of both primary tumors and their metastases, and has a prognostic value for survival after metastasis. We therefore suggest investigation into treatments targeting improvement of MFI as a potential novel strategy.
机构:
Univ Lyon 1, Dept Cancerol Med, Ctr Leon Berard, F-69365 Lyon, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
Bachelot, Thomas
Commo, Frederic
论文数: 0引用数: 0
h-index: 0
机构:
Inst Gustave Roussy, INSERM Unit, U981, Villejuif, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
Commo, Frederic
Campone, Mario
论文数: 0引用数: 0
h-index: 0
机构:
Inst Cancerol Ouest Rene Gauducheau, St Herblain, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
Campone, Mario
Arnedos, Monica
论文数: 0引用数: 0
h-index: 0
机构:
Inst Gustave Roussy, Dept Med Oncol, Villejuif, France
Inst Gustave Roussy, INSERM Unit, U981, Villejuif, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
Arnedos, Monica
Dieras, Veronique
论文数: 0引用数: 0
h-index: 0
机构:
Inst Curie, Dept Med Oncol, Paris, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
Dieras, Veronique
Lacroix-Triki, Magali
论文数: 0引用数: 0
h-index: 0
机构:
Inst Claudius Regaud, Dept Pathol, Toulouse, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
Lacroix-Triki, Magali
Lacroix, Ludovic
论文数: 0引用数: 0
h-index: 0
机构:
Inst Gustave Roussy, Dept Translat Res, Villejuif, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
Lacroix, Ludovic
论文数: 引用数:
h-index:
机构:
Cohen, Pascale
Gentien, David
论文数: 0引用数: 0
h-index: 0
机构:
Inst Curie, Dept Translat Res, Paris, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
Gentien, David
Adelaide, Jose
论文数: 0引用数: 0
h-index: 0
机构:
Inst J Paoli I Calmettes, Dept Mol Oncol, F-13009 Marseille, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
Adelaide, Jose
Dalenc, Florence
论文数: 0引用数: 0
h-index: 0
机构:
Inst Claudius Regaud, Dept Med Oncol, Toulouse, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
Dalenc, Florence
Goncalves, Anthony
论文数: 0引用数: 0
h-index: 0
机构:
Inst J Paoli I Calmettes, Dept Med Oncol, F-13009 Marseille, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
Goncalves, Anthony
Levy, Christelle
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Francois Baclesse, Dept Med Oncol, F-14021 Caen, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
Levy, Christelle
Ferrero, Jean-Marc
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Antoine Lacassagne, Dept Med Oncol, F-06054 Nice, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
Ferrero, Jean-Marc
Bonneterre, Jacques
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Oscar Lambret, Dept Med Oncol, F-59020 Lille, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
Bonneterre, Jacques
Lefeuvre, Claudia
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Eugene Marquis, Dept Med Oncol, Rennes, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
Lefeuvre, Claudia
Jimenez, Marta
论文数: 0引用数: 0
h-index: 0
机构:
UNICANCER, Res & Dev Unit, Paris, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
Jimenez, Marta
Filleron, Thomas
论文数: 0引用数: 0
h-index: 0
机构:
Inst Claudius Regaud, Dept Biostat, Toulouse, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
Filleron, Thomas
Bonnefoi, Herve
论文数: 0引用数: 0
h-index: 0
机构:
Univ Bordeaux, INSERM U916, Dept Med Oncol, Inst Bergonie, Bordeaux, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
机构:
Univ Chicago, Dept Hlth Studies, Chicago, IL 60637 USA
Ctr Biostat, Natl Surg Adjuvant Breast & Bowel Project, Pittsburgh, PA USAUniv Chicago, Dept Hlth Studies, Chicago, IL 60637 USA
Dignam, James J.
Dukic, Vanja
论文数: 0引用数: 0
h-index: 0
机构:
Univ Chicago, Dept Hlth Studies, Chicago, IL 60637 USAUniv Chicago, Dept Hlth Studies, Chicago, IL 60637 USA
Dukic, Vanja
Anderson, Stewart J.
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Biostat, Natl Surg Adjuvant Breast & Bowel Project, Pittsburgh, PA USA
Univ Pittsburgh, Dept Biostat, Pittsburgh, PA 15261 USAUniv Chicago, Dept Hlth Studies, Chicago, IL 60637 USA
Anderson, Stewart J.
Mamounas, Eleftherios P.
论文数: 0引用数: 0
h-index: 0
机构:
NSABP Operat Ctr, Pittsburgh, PA USA
Altman Canc Ctr, Canton, OH USAUniv Chicago, Dept Hlth Studies, Chicago, IL 60637 USA
Mamounas, Eleftherios P.
Wickerham, D. Lawrence
论文数: 0引用数: 0
h-index: 0
机构:
NSABP Operat Ctr, Pittsburgh, PA USAUniv Chicago, Dept Hlth Studies, Chicago, IL 60637 USA
Wickerham, D. Lawrence
Wolmark, Norman
论文数: 0引用数: 0
h-index: 0
机构:
NSABP Operat Ctr, Pittsburgh, PA USAUniv Chicago, Dept Hlth Studies, Chicago, IL 60637 USA
机构:
Univ Texas, Hlth Sci Ctr, Div Med Oncol, Dept Med, San Antonio, TX 78284 USAUniv Texas, Hlth Sci Ctr, Div Med Oncol, Dept Med, San Antonio, TX 78284 USA
Hilsenbeck, SG
Ravdin, PM
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas, Hlth Sci Ctr, Div Med Oncol, Dept Med, San Antonio, TX 78284 USAUniv Texas, Hlth Sci Ctr, Div Med Oncol, Dept Med, San Antonio, TX 78284 USA
Ravdin, PM
de Moor, CA
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas, Hlth Sci Ctr, Div Med Oncol, Dept Med, San Antonio, TX 78284 USAUniv Texas, Hlth Sci Ctr, Div Med Oncol, Dept Med, San Antonio, TX 78284 USA
de Moor, CA
Chamness, GC
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas, Hlth Sci Ctr, Div Med Oncol, Dept Med, San Antonio, TX 78284 USAUniv Texas, Hlth Sci Ctr, Div Med Oncol, Dept Med, San Antonio, TX 78284 USA
Chamness, GC
Osborne, CK
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas, Hlth Sci Ctr, Div Med Oncol, Dept Med, San Antonio, TX 78284 USAUniv Texas, Hlth Sci Ctr, Div Med Oncol, Dept Med, San Antonio, TX 78284 USA
Osborne, CK
Clark, GM
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas, Hlth Sci Ctr, Div Med Oncol, Dept Med, San Antonio, TX 78284 USAUniv Texas, Hlth Sci Ctr, Div Med Oncol, Dept Med, San Antonio, TX 78284 USA
机构:
Univ Lyon 1, Dept Cancerol Med, Ctr Leon Berard, F-69365 Lyon, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
Bachelot, Thomas
Commo, Frederic
论文数: 0引用数: 0
h-index: 0
机构:
Inst Gustave Roussy, INSERM Unit, U981, Villejuif, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
Commo, Frederic
Campone, Mario
论文数: 0引用数: 0
h-index: 0
机构:
Inst Cancerol Ouest Rene Gauducheau, St Herblain, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
Campone, Mario
Arnedos, Monica
论文数: 0引用数: 0
h-index: 0
机构:
Inst Gustave Roussy, Dept Med Oncol, Villejuif, France
Inst Gustave Roussy, INSERM Unit, U981, Villejuif, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
Arnedos, Monica
Dieras, Veronique
论文数: 0引用数: 0
h-index: 0
机构:
Inst Curie, Dept Med Oncol, Paris, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
Dieras, Veronique
Lacroix-Triki, Magali
论文数: 0引用数: 0
h-index: 0
机构:
Inst Claudius Regaud, Dept Pathol, Toulouse, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
Lacroix-Triki, Magali
Lacroix, Ludovic
论文数: 0引用数: 0
h-index: 0
机构:
Inst Gustave Roussy, Dept Translat Res, Villejuif, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
Lacroix, Ludovic
论文数: 引用数:
h-index:
机构:
Cohen, Pascale
Gentien, David
论文数: 0引用数: 0
h-index: 0
机构:
Inst Curie, Dept Translat Res, Paris, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
Gentien, David
Adelaide, Jose
论文数: 0引用数: 0
h-index: 0
机构:
Inst J Paoli I Calmettes, Dept Mol Oncol, F-13009 Marseille, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
Adelaide, Jose
Dalenc, Florence
论文数: 0引用数: 0
h-index: 0
机构:
Inst Claudius Regaud, Dept Med Oncol, Toulouse, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
Dalenc, Florence
Goncalves, Anthony
论文数: 0引用数: 0
h-index: 0
机构:
Inst J Paoli I Calmettes, Dept Med Oncol, F-13009 Marseille, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
Goncalves, Anthony
Levy, Christelle
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Francois Baclesse, Dept Med Oncol, F-14021 Caen, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
Levy, Christelle
Ferrero, Jean-Marc
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Antoine Lacassagne, Dept Med Oncol, F-06054 Nice, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
Ferrero, Jean-Marc
Bonneterre, Jacques
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Oscar Lambret, Dept Med Oncol, F-59020 Lille, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
Bonneterre, Jacques
Lefeuvre, Claudia
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Eugene Marquis, Dept Med Oncol, Rennes, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
Lefeuvre, Claudia
Jimenez, Marta
论文数: 0引用数: 0
h-index: 0
机构:
UNICANCER, Res & Dev Unit, Paris, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
Jimenez, Marta
Filleron, Thomas
论文数: 0引用数: 0
h-index: 0
机构:
Inst Claudius Regaud, Dept Biostat, Toulouse, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
Filleron, Thomas
Bonnefoi, Herve
论文数: 0引用数: 0
h-index: 0
机构:
Univ Bordeaux, INSERM U916, Dept Med Oncol, Inst Bergonie, Bordeaux, FranceInst Gustave Roussy, Dept Med Oncol, Villejuif, France
机构:
Univ Chicago, Dept Hlth Studies, Chicago, IL 60637 USA
Ctr Biostat, Natl Surg Adjuvant Breast & Bowel Project, Pittsburgh, PA USAUniv Chicago, Dept Hlth Studies, Chicago, IL 60637 USA
Dignam, James J.
Dukic, Vanja
论文数: 0引用数: 0
h-index: 0
机构:
Univ Chicago, Dept Hlth Studies, Chicago, IL 60637 USAUniv Chicago, Dept Hlth Studies, Chicago, IL 60637 USA
Dukic, Vanja
Anderson, Stewart J.
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Biostat, Natl Surg Adjuvant Breast & Bowel Project, Pittsburgh, PA USA
Univ Pittsburgh, Dept Biostat, Pittsburgh, PA 15261 USAUniv Chicago, Dept Hlth Studies, Chicago, IL 60637 USA
Anderson, Stewart J.
Mamounas, Eleftherios P.
论文数: 0引用数: 0
h-index: 0
机构:
NSABP Operat Ctr, Pittsburgh, PA USA
Altman Canc Ctr, Canton, OH USAUniv Chicago, Dept Hlth Studies, Chicago, IL 60637 USA
Mamounas, Eleftherios P.
Wickerham, D. Lawrence
论文数: 0引用数: 0
h-index: 0
机构:
NSABP Operat Ctr, Pittsburgh, PA USAUniv Chicago, Dept Hlth Studies, Chicago, IL 60637 USA
Wickerham, D. Lawrence
Wolmark, Norman
论文数: 0引用数: 0
h-index: 0
机构:
NSABP Operat Ctr, Pittsburgh, PA USAUniv Chicago, Dept Hlth Studies, Chicago, IL 60637 USA
机构:
Univ Texas, Hlth Sci Ctr, Div Med Oncol, Dept Med, San Antonio, TX 78284 USAUniv Texas, Hlth Sci Ctr, Div Med Oncol, Dept Med, San Antonio, TX 78284 USA
Hilsenbeck, SG
Ravdin, PM
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas, Hlth Sci Ctr, Div Med Oncol, Dept Med, San Antonio, TX 78284 USAUniv Texas, Hlth Sci Ctr, Div Med Oncol, Dept Med, San Antonio, TX 78284 USA
Ravdin, PM
de Moor, CA
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas, Hlth Sci Ctr, Div Med Oncol, Dept Med, San Antonio, TX 78284 USAUniv Texas, Hlth Sci Ctr, Div Med Oncol, Dept Med, San Antonio, TX 78284 USA
de Moor, CA
Chamness, GC
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas, Hlth Sci Ctr, Div Med Oncol, Dept Med, San Antonio, TX 78284 USAUniv Texas, Hlth Sci Ctr, Div Med Oncol, Dept Med, San Antonio, TX 78284 USA
Chamness, GC
Osborne, CK
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas, Hlth Sci Ctr, Div Med Oncol, Dept Med, San Antonio, TX 78284 USAUniv Texas, Hlth Sci Ctr, Div Med Oncol, Dept Med, San Antonio, TX 78284 USA
Osborne, CK
Clark, GM
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas, Hlth Sci Ctr, Div Med Oncol, Dept Med, San Antonio, TX 78284 USAUniv Texas, Hlth Sci Ctr, Div Med Oncol, Dept Med, San Antonio, TX 78284 USA