Integrated Biomarkers for Depression in Alzheimer's Disease: A Critical Review

被引:6
作者
Wenzler, Sofia [1 ]
Knoechel, Christian [1 ]
Balaban, Ceylan [1 ]
Kraft, Dominik [1 ]
Kopf, Juliane [1 ]
Alves, Gilberto S. [2 ,3 ]
Prvulovic, David [1 ]
Carvalho, Andre F. [2 ,3 ]
Oertel-Knoechel, Viola [1 ]
机构
[1] Goethe Univ, Dept Psychiat Psychosomat Med & Psychotherapy, Lab Neuroimaging, Heinrich Hoffmann Str 10, D-60528 Frankfurt, Germany
[2] Univ Fed Ceara, Fac Med, Translat Psychiat Res Grp, Fortaleza, Ceara, Brazil
[3] Univ Fed Ceara, Fac Med, Dept Clin Med, Fortaleza, Ceara, Brazil
关键词
Alzheimer's disease; depression; biomarkers; depression in Alzheimer's Disease; neuroimaging; neurophysiology; genetics; serum biomarkers; BDNF; MILD COGNITIVE IMPAIRMENT; LATE-LIFE DEPRESSION; WHITE-MATTER MICROSTRUCTURE; GENETIC RISK-FACTORS; DIFFUSION-TENSOR; MAJOR DEPRESSION; DEFAULT-MODE; FUNCTIONAL CONNECTIVITY; AMYLOID ANGIOPATHY; BRAIN ACTIVATION;
D O I
10.2174/1567205013666160603011256
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Depression is a common neuropsychiatric manifestation among Alzheimer's disease (AD) patients. It may compromise everyday activities and lead to a faster cognitive decline as well as worse quality of life. The identification of promising biomarkers may therefore help to timely initiate and improve the treatment of preclinical and clinical states of AD, and to improve the long-term functional outcome. In this narrative review, we report studies that investigated biomarkers for AD-related depression. Genetic findings state AD-related depression as a rather complex, multifactorial trait with relevant environmental and inherited contributors. However, one specific set of genes, the brain derived neurotrophic factor (BDNF), specifically the Val66Met polymorphism, may play a crucial role in AD-related depression. Regarding neuroimaging markers, the most promising findings reveal structural impairments in the cortico-subcortical networks that are related to affect regulation and reward/aversion control. Functional imaging studies reveal abnormalities in predominantly frontal and temporal regions. Furthermore, CSF based biomarkers are seen as potentially promising for the diagnostic process showing abnormalities in metabolic pathways that contribute to AD-related depression. However, there is a need for standardization of methodological issues and for replication of current evidence with larger cohorts and prospective studies.
引用
收藏
页码:441 / 452
页数:12
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