beta-lactams on solid support: Mild and efficient removal of penicillin derivatives from Merrifield resin using aluminum chloride

被引：31

作者：

Mata, EG

机构：

[1] Inst. de Quim. Organ. de Sintesis, 2000 Rosario

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 36期

关键词：

D O I：

10.1016/S0040-4039(97)01457-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Penicillin derivatives linked to Merrifield resin are efficiently released from this support under mild conditions using aluminum chloride in dichloromethane/nitromethane. Extension to Wang resin-linked analogues and studies on the solid-phase oxidation of penicillin is also reported. (C) 1997 Elsevier Science Ltd.

引用

收藏

页码：6335 / 6338

页数：4

相关论文

共 19 条

[1]

[Anonymous], 1996, ACCOUNTS CHEM RES, V29

[2]

BELINZONI DU, 1988, J CHEM RES-S, P176

[3]

BELINZONI DU, 1988, J CHEM RES M, P1501

[4] PENICILLIN SULFOXIDES AND SULFONES [J].

CHOW, AW ;

HOOVER, JRE ;

HALL, NM .

JOURNAL OF ORGANIC CHEMISTRY, 1962, 27 (04) :1381-&

[5] New directions in antibacterial research [J].

Chu, DTW ;

Plattner, JJ ;

Katz, L .

JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (20) :3853-3874

[6] SYNTHESIS AND BETA-LACTAMASE INHIBITORY EVALUATION OF NOVEL 6-ALPHA-HALO-2-BETA-CHLOROMETHYL-2-ALPHA-METHYLPENAM-3-ALPHA-CARBOXYLIC ACIDS AND THEIR SULFONES AND 6-ALPHA-HALO-2-BETA-MERCAPTOBENZOTHIAZOLYLMETHYL-2-ALPHA-METHYLPENAM-3-ALPHA-CARBOXYLIC ACIDS [J].

DANELON, GO ;

MATA, EG ;

MASCARETTI, OA ;

GIRARDINI, J ;

MARRO, M ;

ROVERI, OA .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (17) :2037-2040

[7] Organic chemistry on solid supports [J].

Fruchtel, JS ;

Jung, G .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1996, 35 (01) :17-42

[8] DETERMINATION OF CONFIGURATION OF SOME PENICILLIN S-OXIDES BY C-13 NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPY [J].

HARRISON, CR ;

HODGE, P .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1976, (16) :1772-1775

[9] Solid-phase organic reactions: A review of the recent literature [J].

Hermkens, PHH ;

Ottenheijm, HCJ ;

Rees, D .

TETRAHEDRON, 1996, 52 (13) :4527-4554

[10] COMBINATORIAL CHEMISTRY [J].

LOWE, G .

CHEMICAL SOCIETY REVIEWS, 1995, 24 (05) :309-&