Gold-Catalyzed Direct Oxidative Arylation with Boron Coupling Partners

被引：82

作者：

Hofer, Manuel ^{[1
]}

Genoux, Alexandre ^{[1
]}

Kumar, Roopender ^{[1
]}

Nevado, Cristina ^{[1
]}

机构：

[1] Univ Zurich, Dept Chem, Winterthurerstr 190, CH-8057 Zurich, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 04期

基金：

欧洲研究理事会; 瑞士国家科学基金会;

关键词：

arylation; cross-coupling; gold; homogeneous catalysis; reaction mechanisms; C-H ACTIVATION; BOND FORMATION; TRANSMETALATION REACTION; NONACTIVATED ARENES; ORGANIC-SYNTHESIS; COMPLEXES; ACIDS; FUNCTIONALIZATION; ALKENES; PROTODEBORONATION;

D O I：

10.1002/anie.201610457

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient synthesis of biaryls through a gold-catalyzed oxidative cross-coupling of arenes with strong electron-deprived aryl boronates is presented herein. Regio- and chemocontrol are achieved by the selective activation of these coupling partners by gold at different oxidation states. Under reaction conditions devoid of basic additives or directing groups, the role of acetato ligand as an internal base has been revealed as a key parameter for expanding the reaction scope in these transformations.

引用

页码：1021 / 1025

页数：5

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