Synergistic Catalysis by Copper Oxide/Graphene Oxide Nanocomposites: A Facile Approach to Prepare Quinazolines and Quinazoline Containing Triazole/Tetrazole Moieties under Mild Reaction Conditions

A one-pot three-component strategy for the synthesis of quinazoline derivatives under catalyst-free and using CuO/GO nanocomposite has been developed. The catalytic approach proceeded under mild reaction conditions and offered improved yields of the target products within shorter reaction time. The excellent catalytic performance of CuO/GO can be ascribed to the synergistic interaction of the combined graphene oxide (GO) and nano-sized CuO nanoparticles. A wide variety of substrates, including aromatic, heteroaromatic, and bulky aldehydes were explored to obtain highly functionalized quinazoline products in good to high yields. Furthermore, this atom-efficient catalytic pathway has also been extended for the synthesis of quinazoline containing triazole and tetrazole rings. Additionally, the nanocatalyst could be easily recycled and reused five times without much appreciable loss in its activity.