Anticancer Platelet-Mimicking Nanovehicles

被引：570

作者：

Hu, Quanyin ^{[1
,2
,3
,4
]}

Sun, Wujin ^{[1
,2
,3
,4
]}

Qian, Chengen ^{[1
,2
,3
,4
]}

Wang, Chao ^{[1
,2
,3
,4
]}

Bomba, Hunter N. ^{[1
,2
,3
,4
]}

Gu, Zhen ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ N Carolina, Joint Dept Biomed Engn, Chapel Hill, NC USA

[2] N Carolina State Univ, Raleigh, NC 27695 USA

[3] Univ N Carolina, Eshelman Sch Pharm, Div Mol Pharmaceut, Chapel Hill, NC 27599 USA

[4] Univ N Carolina, Eshelman Sch Pharm, Ctr Nanotechnol Drug Delivery, Chapel Hill, NC 27599 USA

[5] Univ N Carolina, Sch Med, Dept Med, Chapel Hill, NC 27599 USA

来源：

ADVANCED MATERIALS | 2015年 / 27卷 / 44期

基金：

美国国家科学基金会;

关键词：

DRUG-DELIVERY; CANCER-CELLS; P-SELECTIN; NANOPARTICLES; NANOTECHNOLOGY; DISSEMINATION; METASTASIS; MECHANISMS; DISEASE; TARGET;

D O I：

10.1002/adma.201503323

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A core-shell nanovehicle coated with a platelet membrane (PM) is developed for targeted and site-specific delivery of an extracellularly active drug and an intracellular functional small-molecular drug, leading to enhanced antitumor efficacy. This PM-coated nanovehicle can also effectively eliminate the circulating tumor cells in vivo and inhibit development of tumor metastasis.

引用

页码：7043 / +

页数：9

共 49 条

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