Anticancer Platelet-Mimicking Nanovehicles

被引：589
作者：
Hu, Quanyin [1 ,2 ,3 ,4 ]
Sun, Wujin [1 ,2 ,3 ,4 ]
Qian, Chengen [1 ,2 ,3 ,4 ]
Wang, Chao [1 ,2 ,3 ,4 ]
Bomba, Hunter N. [1 ,2 ,3 ,4 ]
Gu, Zhen [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Univ N Carolina, Joint Dept Biomed Engn, Chapel Hill, NC USA
[2] N Carolina State Univ, Raleigh, NC 27695 USA
[3] Univ N Carolina, Eshelman Sch Pharm, Div Mol Pharmaceut, Chapel Hill, NC 27599 USA
[4] Univ N Carolina, Eshelman Sch Pharm, Ctr Nanotechnol Drug Delivery, Chapel Hill, NC 27599 USA
[5] Univ N Carolina, Sch Med, Dept Med, Chapel Hill, NC 27599 USA
来源：
ADVANCED MATERIALS | 2015年 / 27卷 / 44期
基金：
美国国家科学基金会;
关键词：
DRUG-DELIVERY; CANCER-CELLS; P-SELECTIN; NANOPARTICLES; NANOTECHNOLOGY; DISSEMINATION; METASTASIS; MECHANISMS; DISEASE; TARGET;
D O I：
10.1002/adma.201503323
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A core-shell nanovehicle coated with a platelet membrane (PM) is developed for targeted and site-specific delivery of an extracellularly active drug and an intracellular functional small-molecular drug, leading to enhanced antitumor efficacy. This PM-coated nanovehicle can also effectively eliminate the circulating tumor cells in vivo and inhibit development of tumor metastasis.
引用
收藏
页码：7043 / +
页数：9
相关论文
共 49 条
[1]   Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells [J].
Aicher, A ;
Heeschen, C ;
Mildner-Rihm, C ;
Urbich, C ;
Ihling, C ;
Technau-Ihling, K ;
Zeiher, AM ;
Dimmeler, S .
NATURE MEDICINE, 2003, 9 (11) :1370-1376
[2]   Platelet-like Nanoparticles: Mimicking Shape, Flexibility, and Surface Biology of Platelets To Target Vascular Injuries [J].
Anselmo, Aaron C. ;
Modery-Pawlowski, Christa Lynn ;
Menegatti, Stefano ;
Kumar, Sunny ;
Vogus, Douglas R. ;
Tian, Lewis L. ;
Chen, Ming ;
Squires, Todd M. ;
Sen Gupta, Anirban ;
Mitragotri, Samir .
ACS NANO, 2014, 8 (11) :11243-11253
[3]   An aptamer-doxorubicin physical conjugate as a novel targeted drug-delivery platform [J].
Bagalkot, Vaishali ;
Farokhzad, Omid C. ;
Langer, Robert ;
Jon, Sangyong .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (48) :8149-8152
[4]   Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production [J].
Boilard, Eric ;
Nigrovic, Peter A. ;
Larabee, Katherine ;
Watts, Gerald F. M. ;
Coblyn, Jonathan S. ;
Weinblatt, Michael E. ;
Massarotti, Elena M. ;
Remold-O'Donnell, Eileen ;
Farndale, Richard W. ;
Ware, Jerry ;
Lee, David M. .
SCIENCE, 2010, 327 (5965) :580-583
[5]   Heparin and cancer revisited: Mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis [J].
Borsig, L ;
Wong, R ;
Feramisco, J ;
Nadeau, DR ;
Varki, NM ;
Varki, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (06) :3352-3357
[6]   A Perspective on Cancer Cell Metastasis [J].
Chaffer, Christine L. ;
Weinberg, Robert A. .
SCIENCE, 2011, 331 (6024) :1559-1564
[7]   Dissemination and growth of cancer cells in metastatic sites [J].
Chambers, AF ;
Groom, AC ;
MacDonald, IC .
NATURE REVIEWS CANCER, 2002, 2 (08) :563-572
[8]   T-Cell Activation by Antigen-Loaded pH-Sensitive Hydrogel Particles in Vivo: The Effect of Particle Size [J].
Cohen, Joel A. ;
Beaudette, Tristan T. ;
Tseng, William W. ;
Bachelder, Eric M. ;
Mende, Ines ;
Engleman, Edgar G. ;
Frechet, Jean M. J. .
BIOCONJUGATE CHEMISTRY, 2009, 20 (01) :111-119
[9]   Clearance of pathological antibodies using biomimetic nanoparticles [J].
Copp, Jonathan A. ;
Fang, Ronnie H. ;
Luk, Brian T. ;
Hu, Che-Ming J. ;
Gao, Weiwei ;
Zhang, Kang ;
Zhang, Liangfang .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (37) :13481-13486
[10]   Circulating tumor cells, disease progression, and survival in metastatic breast cancer [J].
Cristofanilli, M ;
Budd, GT ;
Ellis, MJ ;
Stopeck, A ;
Matera, J ;
Miller, MC ;
Reuben, JM ;
Doyle, GV ;
Allard, WJ ;
Terstappen, LWMM ;
Hayes, DF .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (08) :781-791
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