A Perspective Review on the Role of Nanomedicine in the Modulation of TNF-TNFR2 Axis in Breast Cancer Immunotherapy

被引：27
作者：
Al-Hatamleh, Mohammad A. I. [1 ]
Ahmad, Suhana [1 ]
Boer, Jennifer C. [2 ]
Lim, JitKang [3 ]
Chen, Xin [4 ]
Plebanski, Magdalena [5 ]
Mohamud, Rohimah [1 ,6 ]
机构：
[1] Univ Sains Malaysia, Sch Med Sci, Dept Immunol, Kubang Kerian 16150, Kelantan, Malaysia
[2] Monash Univ, Dept Immunol & Pathol, Melbourne, Vic 3168, Australia
[3] Univ Sains Malaysia, Sch Chem Engn, George Town 14300, Malaysia
[4] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa 999078, Macau, Peoples R China
[5] RMIT Univ, Sch Hlth & Biomed Sci, Bundoora, Vic 3083, Australia
[6] Univ Sains Malaysia, Hosp Univ Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia
来源：
JOURNAL OF ONCOLOGY | 2019年 / 2019卷
关键词：
RECEPTOR-TYPE II; TNF-ALPHA; NANOPARTICLES; CARCINOMA; CELLS;
D O I：
10.1155/2019/6313242
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In the past decade, nanomedicine research has provided us with highly useful agents (nanoparticles) delivering therapeutic drugs to target cancer cells. The present review highlights nanomedicine applications for breast cancer immunotherapy. Recent studies have suggested that tumour necrosis factor (TNF) and its receptor 2 (TNFR2) expressed on breast cancer cells have important functional consequences. This cytokine/receptor interaction is also critical for promoting highly immune-suppressive phenotypes by regulatory T cells (Tregs). This review generally provides a background for nanoparticles as potential drug delivery agents for immunomodulators and further discusses in depth the potential of TNF antagonists delivery to modulate TNF-TNFR2 interactions and inhibit breast cancer progression.
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页数：13
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