Urinary MCP-1/creatinine in Henoch-Schonlein purpura and its relationship with nephritis

被引:11
作者
Fuentes, Yolanda [1 ]
Maria Hernandez, Ana [1 ]
Garcia-Roca, Pilar [1 ]
Valverde, Saul [2 ]
Fernando Velasquez-Jones, Luis [2 ]
Sosa, German [2 ]
Oswaldo Duarte-Duran, Uriel [2 ]
Ortiz, Lourdes [2 ]
Maldonado, Rocio [3 ]
Faugier, Enrique [3 ]
Ramon-Garcia, Guillermo [4 ]
Medeiros, Mara [1 ]
机构
[1] Hosp Infantil Mexico Dr Federico Gomez, Lab Invest Nefrol, Mexico City 06720, DF, Mexico
[2] Hosp Infantil Mexico Dr Federico Gomez, Dept Nefrol, Mexico City 06720, DF, Mexico
[3] Hosp Infantil Mexico Dr Federico Gomez, Dept Reumatol, Mexico City 06720, DF, Mexico
[4] Hosp Infantil Mexico Dr Federico Gomez, Dept Patol, Mexico City 06720, DF, Mexico
关键词
Henoch-Schonlein purpura nephritis; Macrophage; Proteinuria; Biomarkers; Glomerulonephritis; KIDNEY; VASCULITIS; PROTEIN-1; CHILDREN; DISEASE; LESIONS; INJURY;
D O I
10.1007/s00467-013-2740-0
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Monocyte chemotactic protein-1 (MCP-1) plays a direct role in the infiltration of macrophages and monocytes during the early stages of Henoch-Schonlein purpura (HSP) nephritis. The aim of this study was to compare the urinary MCP-1/creatinine levels in children with and without HSP nephritis and determine if they are associated with the severity of renal lesions. We included 77 patients with HSP and 25 healthy control children. Levels of serum creatinine, urinalysis, and 12-h proteinuria assessments were performed. Urinary MCP-1 levels were determined by ELISA. Fifty-seven patients had nephritis (74 %). Urinary MCP-1/creatinine levels were significantly higher in patients with HSP nephritis (median, 653 pg/mg) compared to those with HSP without nephritis (median, 269 pg/mg) or healthy children (191 pg/mg). In addition, higher MCP-1/creatinine levels were observed in HSP patients who had renal biopsy (median, 1,412 pg/mg) in comparison to HSP patients without renal biopsy (median, 302 pg/mg). The urinary MCP-1 cut-off value of 530 pg/mg could be used to distinguish patients who undergo renal biopsy with a sensitivity of 81 % and specificity of 77 %. Urinary MCP-1/creatinine levels are elevated in the early stages of severe HSP nephritis and can be used as a biomarker for HSP nephritis.
引用
收藏
页码:1047 / 1052
页数:6
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