In vitro study of magnetic particle seeding for implant-assisted-magnetic drug targeting: Seed and magnetic drug carrier particle capture

被引：22

作者：

Aviles, Misael O. ^{[1
]}

Ebner, Armin D. ^{[1
]}

Ritter, James A. ^{[1
]}

机构：

[1] Univ S Carolina, Dept Chem Engn, Swearingen Engn Ctr, Columbia, SC 29208 USA

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2009年 / 321卷 / 10期

基金：

美国国家科学基金会;

关键词：

Magnetic drug targeting; MDT; Drug delivery; High-gradient magnetic separation; HGMS; Ferromagnetic particle; Nanoparticle; Magnetite; Magnetic seed; Magnetic drug carrier particle; DELIVERY; MODEL;

D O I：

10.1016/j.jmmm.2009.02.091

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

An implant-assisted-magnetic drug targeting system using seed particles as the implant to increase the capture of magnetic drug carrier particles (MDCPs) in capillary tissue was studied in vitro. Dextran-coated magnetite particles were used as seeds, polydivinylbenzene magnetite particles were used as MDCPs, and a polyethylene porous cylinder was used as surrogate capillary tissue. The results showed that seeds could be magnetically captured first and then used to magnetically capture the MDCPs, causing a significant increase in their collection compared to when the seeds were absent. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：1586 / 1590

页数：5

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